Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17A | Q9UEE5 | 4/20 | 0.50 |
| ▸ | MYLK4 | Q86YV6 | 2/20 | 0.50 |
| ▸ | NEK3 | P51956 | 1/20 | 0.50 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.50 |
| ▸ | NEK5 | Q6P3R8 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 6/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1633639 | 0.88 | STK17A (0.47) | STK17AMYLK4NEK3LIMK1NEK5 | |
| SCHEMBL1632840 | 0.80 | IKBKB (0.48) | MAP4K1CDK4CCND1CCND3CDK6 | |
| SCHEMBL1633623 | 0.74 | TBK1 (0.51) | STK17AMYLK4NEK3LIMK1NEK5 | |
| SCHEMBL30512125 | 0.71 | MAP4K1 (0.59) | BRAFMAP4K1RAF1 | |
| SCHEMBL1632948 | 0.71 | AURKA (0.55) | STK17AMYLK4NEK3LIMK1NEK5 | |
| SCHEMBL1633340 | 0.71 | BRAF (0.56) | STK17AMYLK4NEK3LIMK1NEK5 | |
| SCHEMBL1632541 | 0.70 | CDK4 (0.45) | STK17AMYLK4CDK4CCND1CCND3 | |
| SCHEMBL1633534 | 0.70 | AURKA (0.56) | STK17AMYLK4NEK3LIMK1NEK5 | |
| SCHEMBL1633567 | 0.69 | BRAF (0.54) | STK17AMYLK4NEK3LIMK1NEK5 | |
| SCHEMBL14146531 | 0.69 | STK17A (0.56) | STK17AMYLK4NEK3LIMK1NEK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |