Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 9/20 | 0.49 |
| ▸ | SRC | P12931 | 4/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | STK4 | Q13043 | 1/20 | 0.41 |
| ▸ | STK3 | Q13188 | 1/20 | 0.41 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.41 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.41 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2806531 | 0.92 | SLC6A4 (0.44) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL2803035 | 0.92 | SLC6A4 (0.44) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL2804139 | 0.92 | FGFR1 (0.50) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL2804174 | 0.92 | FGFR1 (0.50) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL2486950 | 0.92 | FGFR1 (0.50) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL2804561 | 0.91 | FGFR1 (0.47) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL2804075 | 0.89 | FGFR1 (0.52) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL2805303 | 0.89 | FGFR1 (0.51) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL2802640 | 0.88 | FGFR1 (0.43) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL14644888 | 0.86 | MET (0.42) | FGFR1FGFR2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8357694-B2 | Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds | ARQULE, INC. (US) | 2013-01-22 | — | — | US | disclosed |
| US-8357694-B2 | Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds | ARQULE, INC. (US) | 2013-01-22 | — | — | US | disclosed |