Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 8/20 | 0.42 |
| ▸ | ANPEP | P15144 | 4/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.34 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12601580 | 1.00 | ATM (0.47) | ATMMMP2ANPEPDPP4DPP8 | |
| SCHEMBL16350268 | 1.00 | ATM (0.47) | ATMMMP2ANPEPDPP4DPP8 | |
| SCHEMBL19083914 | 0.85 | ATM (0.66) | ATMMMP2ANPEPDPP4DPP8 | |
| SCHEMBL12161943 | 0.78 | ATM (0.52) | ATMMMP2ANPEPCHRNB2CHRNA3 | |
| SCHEMBL16300591 | 0.78 | ATM (0.52) | ATMMMP2ANPEPCHRNB2CHRNA3 | |
| SCHEMBL16300601 | 0.78 | ATM (0.52) | ATMMMP2ANPEPCHRNB2CHRNA3 | |
| SCHEMBL16300600 | 0.78 | ATM (0.52) | ATMMMP2ANPEPCHRNB2CHRNA3 | |
| SCHEMBL16349656 | 0.78 | ATM (0.52) | ATMMMP2ANPEPCHRNB2CHRNA3 | |
| SCHEMBL12562519 | 0.78 | ATM (0.74) | ATMMMP2ANPEPDPP4DPP8 | |
| SCHEMBL27510717 | 0.77 | MMP2 (0.68) | ATMMMP2ANPEPCHRNB2CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592419-B2 | Macrocyclic inhibitors of hepatitis C virus NS3-serine protease | SCHERING CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |