Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.79 |
| ▸ | MEN1 | O00255 | 7/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.76 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.74 |
| ▸ | RAB9A | P51151 | 3/20 | 0.73 |
| ▸ | USP2 | O75604 | 2/20 | 0.69 |
| ▸ | NPC1 | O15118 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | THRB | P10828 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | JAK2 | O60674 | 1/20 | 0.64 |
| ▸ | JAK1 | P23458 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | PPARG | P37231 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14705833 | 0.88 | MEN1 (1.00) | KMT2AMEN1SMN1; SMN2EPHX2RAB9A | |
| SCHEMBL16355155 | 0.88 | KMT2A (0.78) | KMT2AMEN1SMN1; SMN2EPHX2RAB9A | |
| SCHEMBL14705700 | 0.85 | MEN1 (0.73) | KMT2AMEN1SMN1; SMN2EPHX2RAB9A | |
| SCHEMBL31610095 | 0.83 | MEN1 (0.64) | KMT2AMEN1SMN1; SMN2EPHX2RAB9A | |
| SCHEMBL27180217 | 0.81 | LMNA (0.67) | KMT2AMEN1SMN1; SMN2EPHX2RAB9A | |
| SCHEMBL30926578 | 0.81 | LMNA (0.67) | KMT2AMEN1SMN1; SMN2EPHX2RAB9A | |
| SCHEMBL939911 | 0.81 | SMN1; SMN2 (0.71) | KMT2AMEN1SMN1; SMN2EPHX2RAB9A | |
| SCHEMBL31175292 | 0.81 | SMN1; SMN2 (0.71) | KMT2AMEN1SMN1; SMN2EPHX2RAB9A | |
| SCHEMBL18762160 | 0.81 | KMT2A (0.67) | KMT2AMEN1SMN1; SMN2EPHX2RAB9A | |
| SCHEMBL4583569 | 0.79 | TP53 (0.70) | KMT2AMEN1SMN1; SMN2EPHX2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790218-B2 | Small molecule activators of calcium-activated chloride channels and methods of use | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-17 | — | — | US | disclosed |
| US-9790218-B2 | Small molecule activators of calcium-activated chloride channels and methods of use | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-17 | — | — | US | disclosed |
| US-20140378510-A1 | SMALL MOLECULE ACTIVATORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS AND METHODS OF USE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378510-A1 | SMALL MOLECULE ACTIVATORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS AND METHODS OF USE | CLCN2, KCNN1, KCNN2 | KMT2A 4127/4885MEN1 1886/4885SMN1; SMN2 4415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.