Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 7/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 3/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9884248 | 0.82 | PIK3R1 (0.41) | PIK3CDPIK3R1PIK3CAPIK3CGPIK3CB | |
| SCHEMBL936097 | 0.75 | PIK3R1 (0.42) | PIK3CDPIK3R1PIK3CAPIK3CGPIK3CB | |
| SCHEMBL13781779 | 0.73 | PIK3CD (0.49) | PIK3CDPIK3R1PIK3CGPIK3CBPDE4D | |
| SCHEMBL18708965 | 0.72 | PIK3CD (0.38) | PIK3CDPIK3R1PIK3CAPIK3CGPIK3CB | |
| SCHEMBL23287745 | 0.71 | PIK3CD (0.47) | PIK3CDPIK3R1PIK3CAPIK3CGPIK3CB | |
| SCHEMBL935803 | 0.70 | PIK3R1 (0.46) | PIK3CDPIK3R1PIK3CAPIK3CGPIK3CB | |
| SCHEMBL18202899 | 0.70 | PIK3CD (0.39) | PIK3CDPIK3R1PIK3CAPIK3CGPDE4A | |
| SCHEMBL18708426 | 0.69 | PIK3CD (0.53) | PIK3CDPIK3R1PIK3CGPIK3CBPDE4D | |
| SCHEMBL16573077 | 0.69 | PIK3CD (0.47) | PIK3CDPIK3R1PIK3CGPIK3CBPDE4D | |
| SCHEMBL935071 | 0.69 | PIK3CD (0.47) | PIK3CDPIK3R1PIK3CGPIK3CBPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140377258-A1 | Treatment Of Cancers Using PI3 Kinase Isoform Modulators | INFINITY PHARMACEUTICALS, INC. (US) | 2014-12-25 | — | — | US | disclosed |
| US-20140377258-A1 | Treatment Of Cancers Using PI3 Kinase Isoform Modulators | INFINITY PHARMACEUTICALS, INC. (US) | 2014-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140377258-A1 | Treatment Of Cancers Using PI3 Kinase Isoform Modulators | PIK3CA, MCL1, PIK3CB | PIK3CD 4/4885PIK3R1 8/4885PIK3CA 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.