Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.69 |
| ▸ | DRD4 | P21917 | 11/20 | 0.69 |
| ▸ | DRD3 | P35462 | 10/20 | 0.69 |
| ▸ | TP53 | P04637 | 3/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16359935 | 0.98 | DRD2 (0.71) | DRD2DRD4DRD3TP53ALOX15 | |
| SCHEMBL12835040 | 0.93 | TP53 (0.71) | DRD2DRD4DRD3TP53ALOX15 | |
| SCHEMBL24268710 | 0.92 | DRD2 (0.83) | DRD2DRD4DRD3TP53ALOX15 | |
| SCHEMBL12835030 | 0.92 | DRD2 (0.71) | DRD2DRD4DRD3TP53ALOX15 | |
| SCHEMBL8955642 | 0.86 | DRD2 (0.55) | DRD2DRD4DRD3TP53ALOX15 | |
| SCHEMBL18643855 | 0.86 | DRD2 (0.55) | DRD2DRD4DRD3TP53ALOX15 | |
| SCHEMBL26116498 | 0.86 | DRD2 (0.55) | DRD2DRD4DRD3TP53ALOX15 | |
| SCHEMBL18643854 | 0.86 | DRD2 (0.55) | DRD2DRD4DRD3TP53ALOX15 | |
| SCHEMBL2806021 | 0.86 | DRD2 (0.55) | DRD2DRD4DRD3TP53ALOX15 | |
| SCHEMBL13572532 | 0.86 | DRD2 (0.55) | DRD2DRD4DRD3TP53ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008127714-A1 | ADMINISTRATION OF CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES | PTC THERAPEUTICS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |
| WO-2008127715-A1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES | PTC THERAPEUTICS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |