Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 9/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 7/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KIF11 | P52732 | 7/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL764223 | 1.00 | ABCG2 (0.53) | ABCG2ABCB1TP53MAPTSMN1; SMN2 | |
| SCHEMBL8403132 | 0.96 | KIF11 (0.49) | ABCG2ABCB1TP53MAPTSMN1; SMN2 | |
| SCHEMBL764051 | 0.90 | TP53 (0.51) | ABCG2ABCB1TP53MAPTSMN1; SMN2 | |
| SCHEMBL8403152 | 0.90 | ABCG2 (0.55) | ABCG2ABCB1TP53MAPTSMN1; SMN2 | |
| SCHEMBL8404438 | 0.89 | ABCG2 (0.53) | ABCG2ABCB1TP53MAPTSMN1; SMN2 | |
| SCHEMBL11912838 | 0.88 | TP53 (0.53) | ABCG2ABCB1TP53MAPTSMN1; SMN2 | |
| SCHEMBL11912707 | 0.88 | TP53 (0.53) | ABCG2ABCB1TP53MAPTSMN1; SMN2 | |
| Emvododstat SCHEMBL764056 | 0.87 | TP53 (0.62) | ABCG2ABCB1TP53MAPTSMN1; SMN2 | |
| Emvododstat SCHEMBL8509210 | 0.87 | TP53 (0.62) | ABCG2ABCB1TP53MAPTSMN1; SMN2 | |
| Emvododstat SCHEMBL9962251 | 0.87 | TP53 (0.62) | ABCG2ABCB1TP53MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008127715-A1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES | PTC THERAPEUTICS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |