Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 15/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PPM1D | O15297 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10196420 | 1.00 | CETP (0.38) | CETPADORA3LMNAGAAHTT | |
| SCHEMBL16360232 | 0.98 | CETP (0.40) | CETPADORA3LMNAGAAHTT | |
| SCHEMBL10196414 | 0.98 | CETP (0.40) | CETPADORA3LMNAGAAHTT | |
| SCHEMBL10196413 | 0.93 | CETP (0.34) | CETPLMNAGAAHTTCYP1A2 | |
| SCHEMBL16360458 | 0.93 | CETP (0.34) | CETPLMNAGAAHTTCYP1A2 | |
| SCHEMBL664294 | 0.89 | CETP (0.40) | CETPPPM1D | |
| SCHEMBL664507 | 0.87 | CETP (0.42) | CETP | |
| SCHEMBL10196409 | 0.87 | LMNA (0.39) | LMNAGAAHTTCYP1A2CYP2C9 | |
| SCHEMBL16360203 | 0.87 | LMNA (0.39) | LMNAGAAHTTCYP1A2CYP2C9 | |
| SCHEMBL10196423 | 0.85 | LMNA (0.35) | ADORA3LMNAGAAHTTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101424-A1 | TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-08-25 | — | — | WO | disclosed |