Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 9/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 8/20 | 0.44 |
| ▸ | JUN | P05412 | 4/20 | 0.44 |
| ▸ | CDK2 | P24941 | 4/20 | 0.44 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | CCNK | O75909 | 2/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.39 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16360406 | 1.00 | MAPK10 (0.44) | MAPK10MAPK8MAPK9JUNCDK2 | |
| SCHEMBL2493168 | 0.90 | MAPK1 (0.45) | MAPK10MAPK8MAPK9JUNCDK2 | |
| SCHEMBL2492524 | 0.90 | MAPK1 (0.45) | MAPK10MAPK8MAPK9JUNCDK2 | |
| SCHEMBL2493170 | 0.90 | MAPK1 (0.45) | MAPK10MAPK8MAPK9JUNCDK2 | |
| SCHEMBL2492528 | 0.90 | MAPK1 (0.45) | MAPK10MAPK8MAPK9JUNCDK2 | |
| SCHEMBL2492527 | 0.90 | MAPK1 (0.45) | MAPK10MAPK8MAPK9JUNCDK2 | |
| SCHEMBL2489034 | 0.85 | CDK2 (0.41) | MAPK10MAPK8MAPK9JUNCDK2 | |
| SCHEMBL2488139 | 0.82 | MAPK8 (0.46) | MAPK10MAPK8MAPK9JUNCDK2 | |
| SCHEMBL2805602 | 0.81 | FGFR1 (0.37) | MAPK10MAPK8MAPK9JUNCDK2 | |
| SCHEMBL2804240 | 0.81 | FGFR1 (0.37) | MAPK10MAPK8MAPK9JUNCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010078421-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | WO | disclosed |