Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 5/20 | 0.41 |
| ▸ | CCNK | O75909 | 4/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 4/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.41 |
| ▸ | CDK9 | P50750 | 3/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.41 |
| ▸ | CDK7 | P50613 | 3/20 | 0.40 |
| ▸ | CCNH | P51946 | 3/20 | 0.40 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | JUN | P05412 | 4/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2493170 | 0.87 | MAPK1 (0.45) | CDK2CCNKCDK12CCNT1CDK9 | |
| SCHEMBL2493168 | 0.87 | MAPK1 (0.45) | CDK2CCNKCDK12CCNT1CDK9 | |
| SCHEMBL2492524 | 0.87 | MAPK1 (0.45) | CDK2CCNKCDK12CCNT1CDK9 | |
| SCHEMBL2492527 | 0.87 | MAPK1 (0.45) | CDK2CCNKCDK12CCNT1CDK9 | |
| SCHEMBL2492528 | 0.87 | MAPK1 (0.45) | CDK2CCNKCDK12CCNT1CDK9 | |
| SCHEMBL16360384 | 0.85 | MAPK10 (0.44) | CDK2CCNKCDK12CCNT1CDK9 | |
| SCHEMBL16360406 | 0.85 | MAPK10 (0.44) | CDK2CCNKCDK12CCNT1CDK9 | |
| SCHEMBL2488139 | 0.82 | MAPK8 (0.46) | CDK2CCNT1JUNMAPK8MAPK9 | |
| SCHEMBL13126036 | 0.81 | MAPK3 (0.37) | CCNKCDK12CCNT1CDK9CDK7 | |
| SCHEMBL2804817 | 0.80 | FGFR1 (0.41) | FGFR1FGFR2SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379506-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS | ArQule, Inc. (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010078421-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | WO | disclosed |