Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.45 |
| ▸ | F11 | P03951 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | HMGCR | P04035 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654232 | 0.91 | PTPN1 (0.51) | TSHRUSP2KMT2AMEN1POLB | |
| SCHEMBL18654290 | 0.91 | PTPN1 (0.51) | TSHRUSP2KMT2AMEN1POLB | |
| SCHEMBL17850331 | 0.88 | TSHR (0.53) | TSHRUSP2KMT2AMEN1POLB | |
| SCHEMBL17850309 | 0.88 | TSHR (0.53) | TSHRUSP2KMT2AMEN1POLB | |
| SCHEMBL13871578 | 0.86 | TSHR (0.55) | TSHRUSP2KMT2AMEN1POLB | |
| SCHEMBL14199414 | 0.86 | POLB (0.53) | TSHRUSP2KMT2AMEN1POLB | |
| SCHEMBL17850340 | 0.85 | TSHR (0.55) | TSHRUSP2KMT2AMEN1POLB | |
| SCHEMBL13447782 | 0.85 | TSHR (0.55) | TSHRUSP2KMT2AMEN1POLB | |
| SCHEMBL17850321 | 0.85 | TSHR (0.55) | TSHRUSP2KMT2AMEN1POLB | |
| SCHEMBL17552001 | 0.85 | TSHR (0.48) | TSHRUSP2KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011127180-A1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF CD274/PD-L1 GENE | ALNYLAM PHARMACEUTICALS, INC. (US) | 2011-10-13 | — | — | WO | disclosed |