Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 10/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1636672 | 1.00 | P2RX7 (0.50) | P2RX7GPR119MAPK1IDO1 | |
| SCHEMBL2838549 | 0.82 | P2RX7 (0.55) | P2RX7 | |
| SCHEMBL1636809 | 0.82 | P2RX7 (0.55) | P2RX7 | |
| SCHEMBL1637704 | 0.80 | P2RX7 (0.48) | P2RX7GPR119MAPK1 | |
| SCHEMBL1636704 | 0.77 | P2RX7 (0.49) | P2RX7GPR119 | |
| SCHEMBL1636703 | 0.77 | P2RX7 (0.49) | P2RX7MAPK1 | |
| SCHEMBL1636701 | 0.76 | P2RX7 (0.47) | P2RX7GPR119 | |
| SCHEMBL1636699 | 0.76 | P2RX7 (0.48) | P2RX7MAPK1 | |
| SCHEMBL1635930 | 0.76 | P2RX7 (0.50) | P2RX7 | |
| SCHEMBL1637480 | 0.74 | P2RX7 (0.53) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932282-B2 | Imidazolidine carboxamide derivatives as P2X7 modulators | GLAXO GROUP LIMITED (GB) | 2011-04-26 | — | — | US | disclosed |