Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 4/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3475222 | 0.88 | ALDH1A1 (0.50) | KDM4EALDH1A1SMN1; SMN2SLC22A12HCRTR1 | |
| SCHEMBL30731261 | 0.78 | ALDH1A1 (0.46) | KDM4EALDH1A1SMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL17439216 | 0.78 | ALDH1A1 (0.46) | KDM4EALDH1A1SMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL16913933 | 0.78 | ALDH1A1 (0.53) | KDM4EALDH1A1SMN1; SMN2SLC22A12HCRTR1 | |
| SCHEMBL31143251 | 0.74 | ALDH1A1 (0.42) | KDM4EALDH1A1SMN1; SMN2SLC22A12HCRTR1 | |
| SCHEMBL2049041 | 0.74 | ALDH1A1 (0.46) | KDM4EALDH1A1SMN1; SMN2SLC22A12HCRTR1 | |
| SCHEMBL30080735 | 0.73 | ALDH1A1 (0.41) | KDM4EALDH1A1SMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL786015 | 0.73 | ALDH1A1 (0.41) | KDM4EALDH1A1SMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL16904543 | 0.72 | USP30 (0.42) | KDM4EALDH1A1SMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL12541476 | 0.72 | ALDH1A1 (0.44) | KDM4EALDH1A1SMN1; SMN2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611806-A1 | DEUTERIUM-ENRICHED HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Ascepion Pharmaceuticals, Inc. (CN) | 2013-07-10 | — | — | EP | disclosed |
| US-20130165475-A1 | DEUTERIUM-ENRICHED HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | ASCEPION PHARMACEUTICALS, INC. (CN) | 2013-06-27 | — | — | US | disclosed |
| WO-2012028106-A1 | DEUTERIUM-ENRICHED HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | ASCEPION PHARMACEUTICALS, INC. (CN) | 2012-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165475-A1 | DEUTERIUM-ENRICHED HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | CDK2, CDK1, CDK3 | KDM4E 900/4885ALDH1A1 4512/4885SMN1; SMN2 3318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.