Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | CDK4 | P11802 | 3/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16363113 | 0.86 | RAD52 (0.50) | RAD52HTTMAPK1TDP1L3MBTL1 | |
| SCHEMBL16363114 | 0.85 | HTT (0.60) | RAD52HTTMAPK1TDP1L3MBTL1 | |
| SCHEMBL15426085 | 0.82 | KDM7A (0.53) | HTTMAPK1TDP1L3MBTL1KDM7A | |
| SCHEMBL14649657 | 0.82 | KDM7A (0.55) | HTTMAPK1TDP1L3MBTL1KDM7A | |
| SCHEMBL9485662 | 0.78 | ESR1 (0.56) | — | |
| SCHEMBL15426076 | 0.76 | KDM7A (0.49) | HTTMAPK1TDP1L3MBTL1KDM7A | |
| SCHEMBL15003161 | 0.75 | HTT (0.57) | HTTMAPK1TDP1L3MBTL1CYP2C19 | |
| SCHEMBL188449 | 0.73 | HIF1A (0.65) | HTTTDP1CDK4HIF1APOLB | |
| Hydrochloric Acid SCHEMBL5396629 | 0.72 | HIF1A (0.68) | HTTCDK4HIF1APOLBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5257349 | 0.72 | HIF1A (0.68) | HTTCDK4HIF1APOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701654-B2 | Process for preparation of dronedarone by removal of hydroxyl group | SANOFI (FR) | 2017-07-11 | — | — | US | disclosed |
| US-20160075674-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP | SANOFI (FR) | 2016-03-17 | — | — | US | disclosed |
| US-9221778-B2 | Process for preparation of dronedarone by removal of hydroxyl group | SANOFI (FR) | 2015-12-29 | — | — | US | disclosed |
| US-20150005515-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP | SANOFI (FR) | 2015-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160075674-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP | CYP2C9, CYP3A43, CYP7A1 | RAD52 4296/4885HTT 1941/4885MAPK1 1523/4885 |
| US-20150005515-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP | CYP2C9, DHCR7, CYP3A4 | RAD52 4075/4885HTT 1766/4885MAPK1 1415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.