Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.50 |
| ▸ | CDK4 | P11802 | 7/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16363116 | 0.86 | RAD52 (0.52) | RAD52CDK4MAPK1HTTTDP1 | |
| SCHEMBL16363118 | 0.83 | ESR1 (0.51) | KDM7AESR1PGRCHRM2HTR1A | |
| SCHEMBL16363114 | 0.83 | HTT (0.60) | RAD52CDK4MAPTCDK2MAPK1 | |
| SCHEMBL16363112 | 0.76 | HTT (0.54) | TP53MAPTMAPK1HTTTDP1 | |
| SCHEMBL16363117 | 0.72 | ESR1 (0.66) | TP53MAPTESR1PGRCHRM2 | |
| SCHEMBL15613890 | 0.72 | ESR1 (0.70) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL14649659 | 0.71 | ESR1 (0.70) | TP53MAPTESR1PGRCHRM2 | |
| SCHEMBL6552266 | 0.70 | ABCB1 (0.76) | CDK4MAPTMAPK1HTTABCB1 | |
| SCHEMBL15426048 | 0.70 | KDM7A (0.53) | MAPK1HTTTDP1L3MBTL1KDM7A | |
| Hydrochloric Acid SCHEMBL22228312 | 0.69 | ABCB1 (0.74) | CDK4MAPTMAPK1HTTABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701654-B2 | Process for preparation of dronedarone by removal of hydroxyl group | SANOFI (FR) | 2017-07-11 | — | — | US | disclosed |
| US-20160075674-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP | SANOFI (FR) | 2016-03-17 | — | — | US | disclosed |
| US-9221778-B2 | Process for preparation of dronedarone by removal of hydroxyl group | SANOFI (FR) | 2015-12-29 | — | — | US | disclosed |
| US-20150005515-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP | SANOFI (FR) | 2015-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160075674-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP | CYP2C9, CYP3A43, CYP7A1 | RAD52 4296/4885CDK4 4239/4885TP53 4605/4885 |
| US-20150005515-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP | CYP2C9, DHCR7, CYP3A4 | RAD52 4075/4885CDK4 4134/4885TP53 4468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.