SCHEMBL16366286

SCHEMBL16366286

CCc1nn(Cc2ccc(Cl)cc2Cl)c2ccccc12

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.62
CYP3A4 P08684 1/20 0.62
CYP2D6 P10635 1/20 0.62
CYP2C9 P11712 1/20 0.62
TSHR P16473 1/20 0.62
PMP22 Q01453 1/20 0.62
HIF1A Q16665 1/20 0.62
NPSR1 Q6W5P4 1/20 0.62
SLC9A1 P19634 1/20 0.53
SLC22A12 Q96S37 3/20 0.45
LMNA P02545 3/20 0.44
ALDH1A1 P00352 2/20 0.44
MAPT P10636 2/20 0.44
ALOX12 P18054 1/20 0.44
POLB P06746 1/20 0.43
KDM4E B2RXH2 1/20 0.43
GLA P06280 1/20 0.43
HPGD P15428 1/20 0.43
VDR P11473 1/20 0.43
BUB1 O43683 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL928760 0.87 CYP1A2 (0.66) CYP1A2CYP3A4CYP2D6CYP2C9TSHR
SCHEMBL14584085 0.84 CYP1A2 (0.65) CYP1A2CYP3A4CYP2D6CYP2C9TSHR
SCHEMBL19128354 0.81 CYP1A2 (0.65) CYP1A2CYP3A4CYP2D6CYP2C9TSHR
SCHEMBL27941734 0.81 CYP1A2 (0.61) CYP1A2CYP3A4CYP2D6CYP2C9TSHR
SCHEMBL6301330 0.80 SLC22A12 (0.69) CYP1A2CYP3A4CYP2D6CYP2C9TSHR
SCHEMBL1602437 0.79 CYP1A2 (0.62) CYP1A2CYP3A4CYP2D6CYP2C9TSHR
SCHEMBL29562266 0.79 CYP1A2 (0.62) CYP1A2CYP3A4CYP2D6CYP2C9TSHR
SCHEMBL927502 0.78 CYP1A2 (0.64) CYP1A2CYP3A4CYP2D6CYP2C9TSHR
SCHEMBL8381741 0.78 NPSR1 (0.65) CYP1A2CYP3A4CYP2D6CYP2C9TSHR
SCHEMBL6298607 0.77 SLC22A12 (0.54) CYP1A2CYP3A4CYP2D6CYP2C9TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014204856-A1 FATTY ACID ANTICANCER DERIVATIVES AND THEIR USES CATABASIS PHARMACEUTICALS, INC. (US) 2014-12-24 WO disclosed