SCHEMBL1602437

SCHEMBL1602437

CC(C)(O)c1nn(Cc2ccc(Cl)cc2Cl)c2ccccc12

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.62
CYP3A4 P08684 2/20 0.62
CYP2C9 P11712 2/20 0.62
CYP2D6 P10635 1/20 0.62
TSHR P16473 1/20 0.62
PMP22 Q01453 1/20 0.62
HIF1A Q16665 1/20 0.62
NPSR1 Q6W5P4 1/20 0.62
SLC9A1 P19634 1/20 0.50
NPC1 O15118 1/20 0.47
LMNA P02545 4/20 0.45
ALDH1A1 P00352 3/20 0.45
MAPT P10636 1/20 0.45
ALOX12 P18054 1/20 0.45
BUB1 O43683 2/20 0.44
CYP2C19 P33261 1/20 0.42
SLC16A3 O15427 1/20 0.41
SLC16A1 P53985 1/20 0.41
MCTS1 Q9ULC4 1/20 0.41
TASP1 Q9H6P5 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29562266 1.00 CYP1A2 (0.62) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL29562298 0.89 CYP1A2 (0.49) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL1603498 0.89 CYP1A2 (0.49) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL14584085 0.81 CYP1A2 (0.65) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL16366286 0.79 CYP1A2 (0.62) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL928760 0.79 CYP1A2 (0.66) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL19128354 0.78 CYP1A2 (0.65) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL27941734 0.78 CYP1A2 (0.61) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
Lonidamine SCHEMBL7134 0.77 CYP1A2 (1.00) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL21121979 0.77 CYP1A2 (0.82) CYP1A2CYP3A4CYP2C9CYP2D6TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12122751-B2 Processes of making 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives Translatum Medicus Inc. (CA) 2024-10-22 US disclosed
US-20240025859-A1 PROCESSES OF MAKING 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES Translatum Medicus Inc. (CA) 2024-01-25 US disclosed
US-11753382-B2 Processes of making 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives Translatum Medicus Inc. (CA) 2023-09-12 US disclosed
US-20220363646-A1 PROCESSES OF MAKING 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES Translatum Medicus Inc. (CA) 2022-11-17 US disclosed
US-20190336482-A1 COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING OCULAR DISORDERS TRANSLATUM MEDICUS INC (CA) 2019-11-07 US disclosed
EP-2262778-B1 1-BENZYL-3-HYDROXYMETHYLINDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1, CXCR1 AND P40 ACRAF (IT) 2019-08-21 EP disclosed
US-20180221339-A1 COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING OCULAR DISORDERS TRANSLATUM MEDICUS, INC. (CA) 2018-08-09 US disclosed
EP-3310353-A1 COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING OCULAR DISORDERS Translatum Medicus, Inc. (CA) 2018-04-25 EP disclosed
WO-2016203313-A1 COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING OCULAR DISORDERS TRANSLATUM MEDICUS, INC. (CA) 2016-12-22 WO disclosed
US-9255073-B2 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40 AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) 2016-02-09 US disclosed
CN-101965337-B Novel 1-benzil-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40 ACRAF 2013-11-06 CN disclosed
US-20130267704-A1 1-BENZYL-3-HYDROXYMETHYLINDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1, CX3CR1 AND P40 AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.P.A. (IT) 2013-10-10 US disclosed
US-8461194-B2 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and P40 AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A. C. R. A. F. S. P. A. (IT) 2013-06-11 US disclosed
US-20110082141-A1 1-BENZYL-3-HYDROXYMETHYLINDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1, CX3CR1 AND P40 AZIENDE CHIM. RIUN.ANG.FRANC. A.C.R.A.F. S.p.A. (IT) 2011-04-07 US disclosed
EP-2262778-A2 1-BENZYL-3-HYDROXYMETHYLINDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1, CXCR1 AND P40 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A. (IT) 2010-12-22 EP disclosed
WO-2009109616-A2 NOVEL 1-BENZIL-3-HYDROXYMETHYLINDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1, CX3CR1 AND P40 AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) 2009-09-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12122751-B2 Processes of making 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives PCMT1, ICMT, FNTA CYP1A2 594/4885CYP3A4 608/4885CYP2C9 1837/4885
US-20180221339-A1 COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING OCULAR DISORDERS UACA, PDE6C, EYA3 CYP1A2 3432/4885CYP3A4 4561/4885CYP2C9 4765/4885
US-20130267704-A1 1-BENZYL-3-HYDROXYMETHYLINDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1, CX3CR1 AND P40 CX3CR1, CCR2, CCR5 CYP1A2 388/4885CYP3A4 348/4885CYP2C9 674/4885
US-11753382-B2 Processes of making 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives PCMT1, ICMT, FNTA CYP1A2 594/4885CYP3A4 608/4885CYP2C9 1837/4885
US-20240025859-A1 PROCESSES OF MAKING 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES PCMT1, ICMT, FNTA CYP1A2 594/4885CYP3A4 608/4885CYP2C9 1837/4885
US-20190336482-A1 COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING OCULAR DISORDERS UACA, PDE6C, EYA3 CYP1A2 3432/4885CYP3A4 4561/4885CYP2C9 4765/4885
US-20110082141-A1 1-BENZYL-3-HYDROXYMETHYLINDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1, CX3CR1 AND P40 CX3CR1, CCR2, CCR5 CYP1A2 388/4885CYP3A4 348/4885CYP2C9 674/4885
US-20220363646-A1 PROCESSES OF MAKING 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES PCMT1, ICMT, FNTA CYP1A2 594/4885CYP3A4 608/4885CYP2C9 1837/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.