Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | PDE5A | O76074 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | LIPE | Q05469 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27570426 | 0.88 | SMN1; SMN2 (0.47) | PTPN1MAOBSMN1; SMN2RAB9AHPGD | |
| SCHEMBL5778874 | 0.82 | PTPN1 (0.49) | PTPN1SMN1; SMN2RAB9AHPGDNPC1 | |
| SCHEMBL27090061 | 0.82 | KDM1A (0.43) | RAB9ANPC1 | |
| SCHEMBL3596125 | 0.82 | PDE5A (0.46) | MAOBPDE5ASMN1; SMN2RAB9AHPGD | |
| SCHEMBL18209408 | 0.81 | MAPT (0.47) | SMN1; SMN2RAB9AHPGDNPC1 | |
| SCHEMBL1319246 | 0.81 | PTPN1 (0.55) | PTPN1SMN1; SMN2RAB9AHPGDLMNA | |
| SCHEMBL3987117 | 0.79 | PTPN1 (0.52) | PTPN1SMN1; SMN2RAB9AHPGDNPC1 | |
| SCHEMBL27090020 | 0.79 | FFAR1 (0.44) | SMN1; SMN2RAB9AHPGDNPC1THRA | |
| SCHEMBL1894477 | 0.78 | ELANE (0.58) | SMN1; SMN2RAB9AHPGDLMNALIPE | |
| SCHEMBL6807773 | 0.78 | NR1H4 (0.47) | PTPN1SMN1; SMN2RAB9ALMNATHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364700-B1 | Compositions and methods to treat skin diseases characterized by cellular proliferation and angiogenesis | PALOMA PHARMACEUTICALS INC (US) | 2014-12-24 | — | — | EP | disclosed |