Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | BRAF | P15056 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | RAF1 | P04049 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2642554 | 0.82 | KDR (0.47) | KDRHPGDBRAFNPC1RAB9A | |
| SCHEMBL3257638 | 0.82 | KDR (0.47) | KDRHPGDBRAFNPC1RAB9A | |
| SCHEMBL29580736 | 0.82 | CTSA (0.48) | KDRBRAFNPC1RAB9ARAF1 | |
| SCHEMBL171083 | 0.82 | CTSA (0.48) | KDRBRAFNPC1RAB9ARAF1 | |
| SCHEMBL30201887 | 0.82 | KDR (0.47) | KDRHPGDBRAFNPC1RAB9A | |
| SCHEMBL163357 | 0.82 | ANO1 (0.51) | — | |
| SCHEMBL161556 | 0.82 | KDM4C (0.51) | HPGDNPC1RAB9ARAF1PARP1 | |
| SCHEMBL162424 | 0.82 | PARP1 (0.45) | BRAFNPC1RAB9ARAF1PARP1 | |
| SCHEMBL2644050 | 0.81 | KDR (0.46) | KDRHPGDBRAFNPC1RAB9A | |
| SCHEMBL14566951 | 0.81 | KDR (0.48) | KDRHPGDBRAFNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112794821-B | Decarboxylation C (sp3) -N cross-coupling reaction of diacyl peroxide and nitrogen-containing nucleophilic reagent mediated by free radical | 南昌航空大学 | 2022-05-24 | — | — | CN | claimed |
| CN-112679435-B | Alkylation/acylation method adopting photo-oxidation reduction/copper co-catalysis | 南昌航空大学 | 2022-04-15 | — | — | CN | claimed |
| CN-112794821-A | Free radical mediated decarboxylation C (sp) of diacyl peroxide and nitrogen-containing nucleophile3) -N cross-coupling reaction | 南昌航空大学 | 2021-05-14 | — | — | CN | claimed |
| CN-112679435-A | Alkylation/acylation method adopting photo-oxidation reduction/copper co-catalysis | 南昌航空大学 | 2021-04-20 | — | — | CN | claimed |
| CN-112794821-B | Decarboxylation C (sp3) -N cross-coupling reaction of diacyl peroxide and nitrogen-containing nucleophilic reagent mediated by free radical | 南昌航空大学 | 2022-05-24 | — | — | CN | disclosed |
| CN-112679435-B | Alkylation/acylation method adopting photo-oxidation reduction/copper co-catalysis | 南昌航空大学 | 2022-04-15 | — | — | CN | disclosed |
| CN-112794821-A | Free radical mediated decarboxylation C (sp) of diacyl peroxide and nitrogen-containing nucleophile3) -N cross-coupling reaction | 南昌航空大学 | 2021-05-14 | — | — | CN | disclosed |
| CN-112679435-A | Alkylation/acylation method adopting photo-oxidation reduction/copper co-catalysis | 南昌航空大学 | 2021-04-20 | — | — | CN | disclosed |
| US-9856210-B2 | Pharmaceutical composition for prevention and treatment of amyotrophic lateral sclerosis | KYOTO UNIVERSITY (JP) | 2018-01-02 | — | — | US | disclosed |
| EP-2611437-B1 | PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS | UNIV KYOTO (JP) | 2017-03-29 | — | — | EP | disclosed |
| CN-105669564-A | Urea compound and preparation method, medicine composition, intermediate and application thereof | 上海医药工业研究院 | 2016-06-15 | — | — | CN | disclosed |
| CN-102958921-B | Urea compound, preparation method thereof, intermediate thereof and application thereof | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2016-03-23 | — | — | CN | disclosed |
| WO-2012029994-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS | KYOTO UNIVERSITY (JP) | 2012-03-08 | — | — | WO | disclosed |
| US-7612200-B2 | Inhibitors of protein kinases | LOCUS PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-20090192307-A1 | INHIBITORS OF PROTEIN KINASES | LOCUS PHARMACEUTICALS, INC. | 2009-07-30 | — | — | US | disclosed |
| EP-1973408-A2 | INHIBITORS OF PROTEIN KINASES | Locus Pharmaceuticals, Inc. (US) | 2008-10-01 | — | — | EP | disclosed |
| EP-1824843-A2 | INHIBITORS OF PROTEIN KINASES | Locus Pharmaceuticals, Inc. (US) | 2007-08-29 | — | — | EP | disclosed |
| US-20070185098-A1 | Inhibitors of protein kinases | LOCUS PHARMACEUTICALS, INC. (US) | 2007-08-09 | — | — | US | disclosed |
| WO-2007081690-A2 | INHIBITORS OF PROTEIN KINASES | LOCUS PHARMACEUTICALS, INC. (US) | 2007-07-19 | — | — | WO | disclosed |
| WO-2006062984-A2 | INHIBITORS OF PROTEIN KINASES | LOCUS PHARMACEUTICALS, INC. (US) | 2006-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192307-A1 | INHIBITORS OF PROTEIN KINASES | MAP3K20, MAP3K1, MAP3K19 | KDR 960/4885HPGD 2153/4885BRAF 163/4885 |
| US-20070185098-A1 | Inhibitors of protein kinases | MAP3K20, MAP3K1, MAP3K19 | KDR 960/4885HPGD 2153/4885BRAF 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.