Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | NAAA | Q02083 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12801181 | 0.89 | POLB (0.43) | KDM4ERAB9AGAAESR1 | |
| SCHEMBL11652618 | 0.84 | KDM4E (0.52) | KDM4ENAAARAB9AL3MBTL1CSNK2A2 | |
| SCHEMBL11652714 | 0.84 | KDM4E (0.52) | KDM4ENAAARAB9AL3MBTL1CSNK2A2 | |
| SCHEMBL11652486 | 0.84 | KDM4E (0.52) | KDM4ENAAARAB9AL3MBTL1CSNK2A2 | |
| SCHEMBL11652981 | 0.84 | KDM4E (0.52) | KDM4ENAAARAB9AL3MBTL1CSNK2A2 | |
| SCHEMBL11653068 | 0.84 | KDM4E (0.52) | KDM4ENAAARAB9AL3MBTL1CSNK2A2 | |
| SCHEMBL2990440 | 0.82 | KDM4E (0.47) | KDM4EALOX15RAB9AL3MBTL1NPSR1 | |
| SCHEMBL12800947 | 0.82 | HDAC4 (0.45) | HDAC4HDAC1HDAC6 | |
| SCHEMBL11749921 | 0.79 | KDM4E (0.48) | KDM4ENAAARAB9AL3MBTL1CSNK2A2 | |
| SCHEMBL11753542 | 0.79 | KDM4E (0.48) | KDM4ENAAARAB9AL3MBTL1CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932386-B2 | Preparation of 2-amino-thiazole-5-carboxylic-acid derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-04-26 | — | — | US | disclosed |
| US-20090030203-A1 | PREPARATION OF 2-AMINO-THIAZOLE-5-CARBOXYLIC-ACID DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030203-A1 | PREPARATION OF 2-AMINO-THIAZOLE-5-CARBOXYLIC-ACID DERIVATIVES | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, ABAT, AADAT | KDM4E 3987/4885NAAA 100/4885ALOX15 3546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.