Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.41 |
| ▸ | PRCP | P42785 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HTR5A | P47898 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13877241 | 0.83 | SLC6A4 (0.47) | ABCB1ABCG2SLC6A4MAOAPDE5A | |
| SCHEMBL26423539 | 0.77 | ESR1 (0.39) | ABCB1ABCG2SLC6A4ESR1HTR5A | |
| SCHEMBL14627593 | 0.76 | SLC6A4 (0.48) | ABCB1ABCG2SLC6A4MAOAMAOB | |
| SCHEMBL16373177 | 0.74 | ABCB1 (0.41) | ABCB1ABCG2DRD2DRD1SIGMAR1 | |
| SCHEMBL16373146 | 0.73 | SIGMAR1 (0.71) | ABCB1ABCG2SIGMAR1KIF11ESR1 | |
| SCHEMBL13877240 | 0.69 | SLC6A4 (0.46) | SLC6A4MAOAMAOBCYP1A2CYP2D6 | |
| SCHEMBL10689191 | 0.68 | SLC6A4 (0.46) | ABCB1ABCG2SLC6A4DRD1MAOA | |
| SCHEMBL11184992 | 0.68 | CYP3A4 (0.41) | ABCB1ABCG2SLC6A4PDE5ACYP1A2 | |
| SCHEMBL10686601 | 0.68 | SLC6A4 (0.47) | ABCB1ABCG2SLC6A4MAOAMAOB | |
| SCHEMBL13877239 | 0.68 | SLC6A4 (0.43) | SLC6A4MAOAMAOBPGRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014207241-A1 | NEW Na-SUBSTITUTED CARBOLINE COMPOUNDS USABLE FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | ALZPROTECT (FR) | 2014-12-31 | — | — | WO | disclosed |