Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL372577 | 1.00 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL372574 | 1.00 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL372480 | 1.00 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL28575943 | 1.00 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL2460192 | 1.00 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL372478 | 1.00 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL372195 | 1.00 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL132575 | 1.00 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL23012792 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL8845344 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 821 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12557826-B2 | Plant-based milk | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 2026-02-24 | — | — | US | claimed |
| WO-2025264421-A1 | PARTICULATE LAUNDRY SOFTENING WASH ADDITIVE | THE PROCTER & GAMBLE COMPANY (US) | 2025-12-26 | — | — | WO | claimed |
| US-20250382546-A1 | PARTICULATE LAUNDRY SOFTENING WASH ADDITIVE | PROCTER & GAMBLE (US) | 2025-12-18 | — | — | US | claimed |
| US-20250382552-A1 | PARTICULATE LAUNDRY SOFTENING WASH ADDITIVE | PROCTER & GAMBLE (US) | 2025-12-18 | — | — | US | claimed |
| EP-4537831-A2 | PHARMACEUTICAL COMPOSITIONS WITH ANTI-RANKL ANTIBODIES, CALCIUM AND VITAMIN D, SUITABLE FOR THE TREATMENT AND/OR PROPHYLAXIS OF DISORDERS OF THE BONE METABOLISM AND THERAPY-INDUCED SIDE EFFECTS SUCH AS HYPOCALCEMIA | Karl, Christoph (CH) | 2025-04-16 | — | — | EP | claimed |
| EP-4501330-A2 | PHARMACEUTICAL COMPOSITIONS WITH ANTI-RANKL ANTIBODIES, CALCIUM AND VITAMIN D, SUITABLE FOR THE TREATMENT AND/OR PROPHYLAXIS OF DISORDERS OF THE BONE METABOLISM AND THERAPY-INDUCED SIDE EFFECTS SUCH AS HYPOCALCEMIA | Karl, Christoph (CH) | 2025-02-05 | — | — | EP | claimed |
| CN-119158068-A | Elastic degradable nasal hemostatic foam dressing and preparation method thereof | 北京化工大学 | 2024-12-20 | — | — | CN | claimed |
| CN-119079992-A | Layered porous biochar prepared from heavy bio-oil and preparation method and application thereof | 南京林业大学 | 2024-12-06 | — | — | CN | claimed |
| CN-117362012-A | Alkali-resistant wear-resistant corrosion-resistant castable and preparation method thereof | 宜兴市海科窑炉工程有限公司 | 2024-01-09 | — | — | CN | claimed |
| EP-4057824-B1 | PLANT-BASED MILK | NESTLE SA (CH) | 2023-12-27 | — | — | EP | claimed |
| US-20020192309-A1 | Reduction of heartburn episodes after ingestion of orange juice | TROPICANA PRODUCTS, INC. | 2002-12-19 | — | — | US | claimed |
| WO-2002089610-A1 | ORANGE JUICE FOR THE REDUCING OF HEARTBURN | TROPICANA PRODUCTS, INC. (US) | 2002-11-14 | — | — | WO | claimed |
| WO-2002089609-A1 | ORANGE JUICE FOR REDUCING HEARTBURNS | TROPICANA PRODUCTS, INC. (US) | 2002-11-14 | — | — | WO | claimed |
| US-20020025360-A1 | FORTIFIED CONFECTIONERY DELIVERY SYSTEMS AND METHODS OF PREPARATION THEREOF | CITY NATIONAL BANK, AS ADMINISTRATIVE AGENT | 2002-02-28 | — | — | US | claimed |
| US-6096125-A | Ink compositions | XEROX CORPORATION (US) | 2000-08-01 | — | — | US | claimed |
| EP-0966208-A4 | FORTIFIED CONFECTIONERY DELIVERY SYSTEMS AND METHODS OF PREPARATION THEREOF | BRISTOL MYERS SQUIBB CO (US) | 2000-04-26 | — | — | EP | claimed |
| EP-0966208-A1 | FORTIFIED CONFECTIONERY DELIVERY SYSTEMS AND METHODS OF PREPARATION THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-12-29 | — | — | EP | claimed |
| WO-1999026491-A1 | FORTIFIED CONFECTIONERY DELIVERY SYSTEMS AND METHODS OF PREPARATION THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-06-03 | — | — | WO | claimed |
| US-5500668-A | INK JET PRINTING | XEROX CORPORATION (US) | 1996-03-19 | — | — | US | claimed |
| EP-0221880-B1 | PROCESS FOR THE ISOLATION OF HIGH-PURITY TRI-CALCIUM CITRATE FROM AQUEOUS SOLUTIONS CONTAINING CITRIC ACID | VOGELBUSCH GESELLSCHAFT m.b.H. (AT) | 1989-08-02 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12557826-B2 | Plant-based milk | PCTP, PROC, S100P | CA4 181/4885ALDH1A1 4702/4885CASP1 4617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.