PCTP — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1233504	1.00	12/20
SCHEMBL1234435	1.00	12/20
SCHEMBL1235186	1.00	12/20
SCHEMBL1235844	1.00	12/20
SCHEMBL1235824	0.72	12/20
SCHEMBL1234441	0.71	12/20
SCHEMBL1233503	1.00	11/20
SCHEMBL1234444	1.00	11/20
SCHEMBL1234456	1.00	11/20
SCHEMBL1234489	1.00	11/20
SCHEMBL1234495	1.00	11/20
SCHEMBL1235095	1.00	11/20
SCHEMBL1235185	1.00	11/20
SCHEMBL1235198	1.00	11/20
SCHEMBL1235816	1.00	11/20
SCHEMBL1234605	0.79	11/20
SCHEMBL1234494	0.78	11/20
SCHEMBL1235208	0.71	11/20
SCHEMBL1235093	1.00	10/20
SCHEMBL1235205	1.00	10/20

Clinical trials — most relevant to PCTP by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Low HDL On Six Weeks Statin Therapy (LOW) Study	PHASE4	UNKNOWN
The HDL Particle Protection Study	PHASE4	COMPLETED
COlchicine for the Prevention of Post Electrical Cardioversion Recurrence of AF	PHASE3	WITHDRAWN
Phospholipovit vs Placebo in Patients With Combined Hyperlipidemia	PHASE2/PHASE3	COMPLETED
Effects of Pioglitazone on High-density Lipoprotein (HDL) Function in Persons With Diabetes	PHASE3	COMPLETED
NEO100 and High-Grade Meningioma	PHASE2	RECRUITING
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides	PHASE1	COMPLETED
Egg Intake, Metabolic Outcomes and Choline Levels	nan	RECRUITING
Association of SGLT2 Inhibitors Therapy With Elastographic and Molecular Markers of Liver Injury in Type 2 Diabetes	nan	COMPLETED
Development of Biomarker for Development of Non-Alcoholic Steatohepatitis (NASH) in Children	nan	WITHDRAWN
Evaluation of HDL Subfraction Changes and HDL-Associated Enzymes in Liver Failure Patients and Healthy Donors	nan	COMPLETED
the Role of plin5 in the Development of Nonalcoholic Fatty Liver Disease.	nan	UNKNOWN
Canagliflozin on Liver Inflammation Damage in Type 2 Diabetes Patients With Nonalcoholic Fatty Liver Disease	nan	UNKNOWN
Association Between HDL Functions and Atherosclerotic Burden in Healthy Individuals	nan	COMPLETED
The Association of SAA With Apolipoprotein B Affects Cardiovascular Risk	nan	COMPLETED
Choline to Improve Malnutrition and Enhance Cognition	nan	RECRUITING
Effect of a Black Garlic Extract on Cholesterol LDL Levels	nan	COMPLETED
The Association Between LPCAT1 Genetic Polymorphism and Stress Biomarkers in Neonatal Respiratory Distress Syndrome	nan	UNKNOWN
Genetic and Metabolism of Post-prandial HDL Particles	nan	COMPLETED
RCDP Natural History Study	nan	UNKNOWN
Impact Of Choline in Patients With NAFLD	nan	UNKNOWN
Effect of Saturated Fat on Large Low-density Lipoprotein (LDL) and High-density Lipoprotein (HDL)	nan	COMPLETED
Assessment Of Lipid Profile In Cirrhotic Patients	nan	COMPLETED
The Effect Of DAAs on miRNA-122 And Insulin Resistance In Chronic HCV Patients	nan	UNKNOWN
In Vivo Metabolism of apoB-containing Lipoproteins in ANGPTL3 Deficient Subjects	nan	UNKNOWN
Epidemiology of Atherosclerosis	nan	COMPLETED
Relationship of Haptoglobin Phenotype to Vascular Function and Response to Vitamin E Supplementation in Patients With Diabetes Mellitus Type 2: The EVAS Trial	nan	UNKNOWN
Effects of Choline From Eggs vs. Supplements on the Generation of TMAO in Humans	nan	COMPLETED
Advanced Lipoproptein Profiling and Cardiovascular Risk Stratification in Familial Hypercholesterolemia	nan	UNKNOWN
Choline PET/CT vs. Dual Time Point FDG PET/CT in Prostate Cancer	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PCTP binder may also engage these)

Protein	Name	Similarity
P53809	—	0.993	P53809 →
P53808	—	0.991	P53808 →
P02720	—	0.985	P02720 →
Q5R8P9	—	0.930	Q5R8P9 →
Q9NSY2	—	0.924	Q9NSY2 →
STARD10	START domain-containing protein 10	0.917	landscape →
Q9JMD3	—	0.912	Q9JMD3 →
A1A4M6	—	0.909	A1A4M6 →
Q8R1R3	—	0.897	Q8R1R3 →
NT5C3B	7-methylguanosine phosphate-specific 5'-nucleotidase	0.894	landscape →
Q8BGA8	—	0.894	Q8BGA8 →
Q8R2J9	—	0.891	Q8R2J9 →
STARD7	StAR-related lipid transfer protein 7, mitochondrial	0.891	landscape →
Q6NUN0	—	0.890	Q6NUN0 →
O43502	—	0.889	O43502 →
Q924H5	—	0.888	Q924H5 →
Q8TCT0	—	0.887	Q8TCT0 →
Q8VHQ9	—	0.887	Q8VHQ9 →
Q8K4Q7	—	0.887	Q8K4Q7 →
Q3UFY7	—	0.886	Q3UFY7 →
A2AIG8	—	0.886	A2AIG8 →
Q1RMS5	—	0.886	Q1RMS5 →
O54783	—	0.885	O54783 →
Q6AYT9	—	0.885	Q6AYT9 →
Q96RR1	—	0.885	Q96RR1 →
ACSL6	Long-chain-fatty-acid--CoA ligase 6	0.884	landscape →
O14734	—	0.884	O14734 →
O54909	—	0.884	O54909 →
Q8R107	—	0.883	Q8R107 →
Q8VCE6	—	0.883	Q8VCE6 →