Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 6/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.33 |
| ▸ | PIK3R5 | Q8WYR1 | 6/20 | 0.33 |
| ▸ | PIK3R3 | Q92569 | 6/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | UGCG | Q16739 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16377693 | 0.94 | PIK3CD (0.35) | ALDH1A1PIK3CDPIK3R2PIK3CAPIK3CB | |
| SCHEMBL16377696 | 0.93 | UGCG (0.34) | ALDH1A1PIK3CDPIK3R2PIK3CAPIK3CB | |
| SCHEMBL20579991 | 0.93 | UGCG (0.34) | ALDH1A1PIK3CDPIK3R2PIK3CAPIK3CB | |
| SCHEMBL16377694 | 0.93 | UGCG (0.34) | ALDH1A1PIK3CDPIK3R2PIK3CAPIK3CB | |
| SCHEMBL16377690 | 0.93 | PIK3CD (0.33) | ALDH1A1PIK3CDPIK3R2PIK3CAPIK3CB | |
| SCHEMBL16378003 | 0.92 | PIK3CD (0.33) | ALDH1A1PIK3CDPIK3R2PIK3CAPIK3CB | |
| SCHEMBL16377793 | 0.92 | PIK3CD (0.33) | ALDH1A1PIK3CDPIK3R2PIK3CAPIK3CB | |
| SCHEMBL16339426 | 0.92 | PIK3CD (0.34) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL16377691 | 0.91 | PIK3CD (0.37) | ALDH1A1PIK3CDPIK3R2PIK3CAPIK3CB | |
| SCHEMBL20580158 | 0.91 | PIK3CD (0.37) | ALDH1A1PIK3CDPIK3R2PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11365199-B2 | Pyrazole compounds as modulators of FSHR and uses thereof | MERCK PATENT GMBH (DE) | 2022-06-21 | — | — | US | disclosed |
| US-11365199-B2 | Pyrazole compounds as modulators of FSHR and uses thereof | MERCK PATENT GMBH (DE) | 2022-06-21 | — | — | US | disclosed |
| EP-3013832-B1 | PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | MERCK PATENT GMBH (DE) | 2020-11-04 | — | — | EP | disclosed |
| EP-3013832-B1 | PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | MERCK PATENT GMBH (DE) | 2020-11-04 | — | — | EP | disclosed |
| US-20180354965-A1 | PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | MERCK PATENT GMBH (DE) | 2018-12-13 | — | — | US | disclosed |
| US-10081637-B2 | Pyrazole compounds as modulators of FSHR and uses thereof | MERCK PATENT GMBH (DE) | 2018-09-25 | — | — | US | disclosed |
| US-20160152626-A1 | PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | MERCK PATENT GMBH (DE) | 2016-06-02 | — | — | US | disclosed |
| US-20160152626-A1 | PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | MERCK PATENT GMBH (DE) | 2016-06-02 | — | — | US | disclosed |
| US-20160152626-A1 | PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | MERCK PATENT GMBH (DE) | 2016-06-02 | — | — | US | disclosed |
| WO-2014209980-A1 | PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | MERCK PATENT GMBH (DE) | 2014-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11365199-B2 | Pyrazole compounds as modulators of FSHR and uses thereof | FSHR, GNRHR, LHCGR | ALDH1A1 4610/4885PKM 1140/4885PIK3CD 927/4885 |
| US-10081637-B2 | Pyrazole compounds as modulators of FSHR and uses thereof | FSHR, GNRHR, LHCGR | ALDH1A1 4610/4885PKM 1140/4885PIK3CD 927/4885 |
| US-20160152626-A1 | PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | FSHR, GNRHR, LHCGR | ALDH1A1 4610/4885PKM 1140/4885PIK3CD 927/4885 |
| US-20180354965-A1 | PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | FSHR, GNRHR, LHCGR | ALDH1A1 4610/4885PKM 1140/4885PIK3CD 927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.