Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1310490 | 0.89 | LMNA (0.53) | LMNAMAPK1PIK3CAPIK3CBTSHR | |
| SCHEMBL1310092 | 0.86 | LMNA (0.50) | LMNAMAPK1PIK3CAPIK3CBTSHR | |
| SCHEMBL1309544 | 0.85 | PIK3CA (0.61) | LMNAMAPK1PIK3CAPIK3CBPIK3CD | |
| SCHEMBL1311222 | 0.78 | PIK3CA (0.60) | LMNAMAPK1PIK3CAPIK3CBTSHR | |
| SCHEMBL1310077 | 0.78 | LMNA (0.55) | LMNAMAPK1PIK3CAPIK3CBTSHR | |
| SCHEMBL1310153 | 0.75 | PIK3CD (0.57) | LMNAMAPK1PIK3CAPIK3CBTSHR | |
| SCHEMBL1310913 | 0.73 | PIK3CA (0.58) | LMNAMAPK1PIK3CAPIK3CBTSHR | |
| SCHEMBL1309730 | 0.73 | LMNA (0.64) | LMNAMAPK1PIK3CAPIK3CBTSHR | |
| SCHEMBL1311889 | 0.73 | PIK3CA (0.55) | LMNAMAPK1PIK3CAPIK3CBTSHR | |
| SCHEMBL1311958 | 0.73 | LMNA (0.60) | LMNAMAPK1PIK3CAPIK3CBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921361-B2 | Triazine, pyrimidine and pyridine analogs and their use as therapeutic agents and diagnostic probes | UNIVERSITY OF BASEL (CH) | 2014-12-30 | — | — | US | disclosed |