Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.39 |
| ▸ | GRAMD1A | Q96CP6 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | F12 | P00748 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17327921 | 0.90 | ESR2 (0.51) | MAPTESR2NR1H2MAPK1ADORA1 | |
| SCHEMBL16217165 | 0.85 | MAPT (0.54) | MAPTESR2NR1H2PDK2MAPK1 | |
| SCHEMBL16220604 | 0.84 | MAPT (0.53) | MAPTESR2NR1H2PDK2MAPK1 | |
| SCHEMBL29383213 | 0.81 | MAPT (0.50) | MAPTESR2NR1H2PDK2MAPK1 | |
| SCHEMBL16210543 | 0.81 | MAPT (0.50) | MAPTESR2NR1H2PDK2MAPK1 | |
| SCHEMBL1879943 | 0.80 | MAPT (0.49) | MAPTESR2NR1H2PDK2MAPK1 | |
| SCHEMBL7989242 | 0.80 | HTT (0.51) | MAPTESR2NR1H2PDK2MAPK1 | |
| SCHEMBL12540737 | 0.79 | GRM1 (0.53) | MAPTESR2NR1H2PDK2MAPK1 | |
| SCHEMBL1016779 | 0.79 | MAPT (0.48) | MAPTESR2NR1H2PDK2MAPK1 | |
| SCHEMBL25447282 | 0.78 | MAPT (0.47) | MAPTESR2NR1H2PDK2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296761-B2 | Triazine derivatives | PFIZER INC. (US) | 2016-03-29 | — | — | US | disclosed |
| US-20150353579-A1 | Triazine Derivatives | PFIZER (US) | 2015-12-10 | — | — | US | disclosed |
| US-9145427-B2 | Triazine derivatives | PFIZER INC. (US) | 2015-09-29 | — | — | US | disclosed |
| US-20150080401-A1 | Triazine Derivatives | PFIZER (US) | 2015-03-19 | — | — | US | disclosed |
| US-8933224-B2 | Triazine derivatives | PFIZER INC. (US) | 2015-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353579-A1 | Triazine Derivatives | PDE12, PDE5A, PDE10A | MAPT 3633/4885ESR2 2152/4885NR1H2 869/4885 |
| US-20150080401-A1 | Triazine Derivatives | PDE12, PDE5A, PDE10A | MAPT 3633/4885ESR2 2152/4885NR1H2 869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.