Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30308269 | 1.00 | MAPT (0.46) | MAPTGAAPTGS1ALDH1A1HSD17B10 | |
| SCHEMBL8233747 | 0.81 | ALDH1A1 (0.49) | MAPTGAAALDH1A1HSD17B10CFTR | |
| SCHEMBL25294776 | 0.78 | PTPN1 (0.55) | MAPTGAAALDH1A1HPGDNPC1 | |
| SCHEMBL11772974 | 0.78 | HPGD (0.50) | MAPTGAAALDH1A1HSD17B10P2RX1 | |
| SCHEMBL6441101 | 0.78 | MAPT (0.47) | MAPTGAAPTGS1ALDH1A1HSD17B10 | |
| SCHEMBL7754046 | 0.78 | MAPT (0.50) | MAPTGAAPTGS1ALDH1A1HSD17B10 | |
| SCHEMBL2636944 | 0.75 | MAPT (0.52) | MAPTGAAALDH1A1HSD17B10CFTR | |
| SCHEMBL10572853 | 0.75 | MAPT (0.52) | MAPTGAAALDH1A1HSD17B10CFTR | |
| SCHEMBL28527938 | 0.74 | MAPT (0.47) | MAPTGAAPTGS1ALDH1A1HSD17B10 | |
| SCHEMBL27484660 | 0.74 | AKR1C3 (0.55) | MAPTGAAALDH1A1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117843651-B | Tetrahydrofuran [3,2-b ] indoline compound containing trifluoromethyl quaternary carbon center and preparation method thereof | 盐城工学院 | 2024-09-10 | — | — | CN | claimed |
| CN-116082269-B | 1,3, 4-Oxazoline compound containing trifluoromethyl quaternary carbon center and preparation method thereof | 盐城工学院 | 2024-06-21 | — | — | CN | claimed |
| CN-117843651-A | Tetrahydrofuran [3,2-b ] indoline compound containing trifluoromethyl quaternary carbon center and preparation method thereof | 盐城工学院 | 2024-04-09 | — | — | CN | claimed |
| CN-116082269-A | 1,3, 4-oxazoline compound containing trifluoromethyl quaternary carbon center and preparation method thereof | 盐城工学院 | 2023-05-09 | — | — | CN | claimed |
| CN-117843651-B | Tetrahydrofuran [3,2-b ] indoline compound containing trifluoromethyl quaternary carbon center and preparation method thereof | 盐城工学院 | 2024-09-10 | — | — | CN | disclosed |
| CN-116082269-B | 1,3, 4-Oxazoline compound containing trifluoromethyl quaternary carbon center and preparation method thereof | 盐城工学院 | 2024-06-21 | — | — | CN | disclosed |
| CN-117843651-A | Tetrahydrofuran [3,2-b ] indoline compound containing trifluoromethyl quaternary carbon center and preparation method thereof | 盐城工学院 | 2024-04-09 | — | — | CN | disclosed |
| CN-116082269-A | 1,3, 4-oxazoline compound containing trifluoromethyl quaternary carbon center and preparation method thereof | 盐城工学院 | 2023-05-09 | — | — | CN | disclosed |
| US-20110098483-A1 | Substituted Nitrogen Heterocycles and Synthesis and Uses Thereof | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2011-04-28 | — | — | US | disclosed |
| US-20110098483-A1 | Substituted Nitrogen Heterocycles and Synthesis and Uses Thereof | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2011-04-28 | — | — | US | disclosed |
| US-20110098483-A1 | Substituted Nitrogen Heterocycles and Synthesis and Uses Thereof | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2011-04-28 | — | — | US | disclosed |
| WO-2009121033-A2 | SUBSTITUTED NITROGEN HETEROCYCLES AND SYNTHESIS AND USES THEREOF | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2009-10-01 | — | — | WO | disclosed |
| US-20090247766-A1 | Substituted Nitrogen Heterocycles and Synthesis and Uses Thereof | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2009-10-01 | — | — | US | disclosed |
| US-20090247766-A1 | Substituted Nitrogen Heterocycles and Synthesis and Uses Thereof | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2009-10-01 | — | — | US | disclosed |
| US-20090247766-A1 | Substituted Nitrogen Heterocycles and Synthesis and Uses Thereof | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098483-A1 | Substituted Nitrogen Heterocycles and Synthesis and Uses Thereof | PAH, NAT1, NNT | MAPT 3189/4885GAA 1143/4885PTGS1 156/4885 |
| US-20090247766-A1 | Substituted Nitrogen Heterocycles and Synthesis and Uses Thereof | PAH, NAT1, NNT | MAPT 3189/4885GAA 1143/4885PTGS1 156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.