Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13617388 | 0.88 | MAOB (0.46) | MAOBEPHX2HDAC6VNN1ERN1 | |
| Benzene SCHEMBL27710673 | 0.85 | MAOB (0.47) | MAOBEPHX2HDAC6VNN1ERN1 | |
| SCHEMBL16121258 | 0.84 | ACE2 (0.53) | EPHX2 | |
| SCHEMBL403117 | 0.82 | PDE3B (0.43) | MAOBEPHX2HDAC6VNN1AR | |
| SCHEMBL16380698 | 0.82 | SLC6A2 (0.54) | MAOBEPHX2HDAC6ARSLC6A2 | |
| SCHEMBL16140748 | 0.82 | PKM (0.56) | MAOBEPHX2HDAC6HSP90AA1HSP90AB1 | |
| SCHEMBL2709797 | 0.81 | AR (0.45) | MAOBVNN1ERN1PARP1PDK2 | |
| Hydrochloric Acid SCHEMBL27741712 | 0.79 | AR (0.44) | MAOBVNN1ERN1PARP1PDK2 | |
| SCHEMBL16140755 | 0.79 | GSK3B (0.54) | EPHX2HDAC6HSP90AA1HSP90AB1 | |
| SCHEMBL2777362 | 0.79 | DDR1 (0.51) | OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014206344-A1 | FUSED TRICYCLIC AMIDE COMPOUNDS AS MULTIPLE KINASE INHIBITORS | BEIGENE, LTD. (GB) | 2014-12-31 | — | — | WO | disclosed |