Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 2/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.36 |
| ▸ | CPB1 | P15086 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TLR2 | O60603 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16384385 | 0.86 | FOLH1 (0.41) | CACNA1BFOLH1ALDH1A1NOD1FNTA | |
| SCHEMBL16384377 | 0.84 | CYP2D6 (0.45) | CACNA1BFOLH1ALDH1A1NOD1FNTA | |
| SCHEMBL25357890 | 0.83 | FOLH1 (0.43) | CACNA1BFOLH1ALDH1A1NOD1FNTA | |
| SCHEMBL25360859 | 0.83 | FOLH1 (0.43) | CACNA1BFOLH1ALDH1A1NOD1FNTA | |
| SCHEMBL25357888 | 0.83 | FOLH1 (0.43) | CACNA1BFOLH1ALDH1A1NOD1FNTA | |
| SCHEMBL16384474 | 0.81 | FOLH1 (0.41) | CACNA1BFOLH1NOD1FNTAFNTB | |
| SCHEMBL19992546 | 0.80 | DPP7 (0.49) | NOD1 | |
| SCHEMBL23408829 | 0.80 | NOD1 (0.41) | FOLH1MMP8CAPN1NOD1FNTA | |
| SCHEMBL15302107 | 0.79 | FOLH1 (0.47) | FOLH1NOD1FNTAFNTB | |
| SCHEMBL24259717 | 0.78 | KMT2A (0.50) | CACNA1BFOLH1ALDH1A1NOD1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150005319-A1 | MACROCYCLIC COMPOUNDS FOR MODULATING IL-17 | ENSEMBLE THERAPEUTICS CORPORATION | 2015-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150005319-A1 | MACROCYCLIC COMPOUNDS FOR MODULATING IL-17 | IL17A, IL15, IL2 | CACNA1B 4384/4885FOLH1 3122/4885MMP8 537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.