Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 11/20 | 0.45 |
| ▸ | TNKS | O95271 | 5/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.41 |
| ▸ | PARP1 | P09874 | 4/20 | 0.41 |
| ▸ | MGLL | Q99685 | 2/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16384441 | 0.91 | EGLN1 (0.39) | EGLN1TNKSTNKS2PARP1MGLL | |
| SCHEMBL3027014 | 0.83 | EGLN1 (0.65) | EGLN1 | |
| SCHEMBL16857753 | 0.81 | EGLN1 (0.47) | EGLN1TNKSTNKS2PARP1MGLL | |
| SCHEMBL10633927 | 0.76 | EGLN1 (0.54) | EGLN1MGLLALKBH3 | |
| SCHEMBL3026665 | 0.76 | EGLN1 (0.58) | EGLN1 | |
| SCHEMBL16384479 | 0.75 | PARP1 (0.35) | EGLN1TNKSTNKS2PARP1 | |
| SCHEMBL10637865 | 0.73 | EGLN1 (0.51) | EGLN1MGLLALKBH3 | |
| SCHEMBL16857723 | 0.73 | EGLN1 (0.42) | EGLN1TNKSTNKS2MGLL | |
| SCHEMBL3799865 | 0.72 | EGLN1 (0.55) | EGLN1 | |
| SCHEMBL3799863 | 0.71 | EGLN1 (0.47) | EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937078-B2 | Quinazolinones as prolyl hydroxylase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-20 | — | — | US | claimed |