Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 5/20 | 0.44 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | WHR1 | P49842 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7700554 | 0.82 | TP53 (0.49) | KCNA5KCNE1IDH1HRH3MAPT | |
| SCHEMBL16230438 | 0.80 | KCNA5 (0.42) | KCNA5KCNE1IDH1HRH3MAPT | |
| SCHEMBL12125610 | 0.79 | IDH1 (0.44) | KCNA5KCNE1IDH1HRH3MAPT | |
| SCHEMBL9963447 | 0.78 | IDH1 (0.47) | KCNA5KCNE1IDH1HRH3MAPT | |
| SCHEMBL11840848 | 0.76 | ALDH1A1 (0.46) | KCNA5KCNE1IDH1HRH3MAPT | |
| SCHEMBL9963444 | 0.73 | KCNA5 (0.50) | KCNA5KCNE1IDH1HRH3CYP2D6 | |
| SCHEMBL16218248 | 0.72 | CHRM2 (0.47) | HRH3MAPTALDH1A1KCNH2 | |
| SCHEMBL9963415 | 0.71 | IDH1 (0.41) | KCNA5KCNE1IDH1HRH3MAPT | |
| SCHEMBL9963414 | 0.71 | IDH1 (0.41) | KCNA5KCNE1IDH1HRH3MAPT | |
| SCHEMBL19111213 | 0.70 | HRH3 (0.57) | HRH3CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8933077-B2 | Glucokinase activators | ARRAY BIOPHARMA INC. (US) | 2015-01-13 | — | — | US | disclosed |