Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 20/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL386785 | 0.87 | GPR119 (0.80) | GPR119CYP2C9KCNH2 | |
| SCHEMBL14823309 | 0.86 | GPR119 (0.71) | GPR119CYP2C9KCNH2 | |
| SCHEMBL390295 | 0.85 | GPR119 (0.77) | GPR119CYP2C9KCNH2 | |
| SCHEMBL391746 | 0.84 | GPR119 (0.76) | GPR119CYP2C9KCNH2 | |
| SCHEMBL14823333 | 0.84 | GPR119 (0.73) | GPR119CYP2C9KCNH2 | |
| SCHEMBL389617 | 0.82 | GPR119 (0.73) | GPR119CYP2C9KCNH2 | |
| SCHEMBL14823308 | 0.82 | GPR119 (0.73) | GPR119CYP2C9KCNH2 | |
| SCHEMBL388233 | 0.82 | GPR119 (0.72) | GPR119CYP2C9KCNH2 | |
| SCHEMBL12241594 | 0.82 | GPR119 (0.85) | GPR119CYP2C9KCNH2 | |
| SCHEMBL389295 | 0.81 | GPR119 (0.74) | GPR119CYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382203-B1 | BICYCLIC HETEROCYCLE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME (US) | 2015-01-14 | — | — | EP | disclosed |