Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.79 |
| ▸ | MAPT | P10636 | 8/20 | 0.79 |
| ▸ | HTT | P42858 | 4/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.79 |
| ▸ | LMNA | P02545 | 3/20 | 0.79 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.79 |
| ▸ | PGR | P06401 | 1/20 | 0.75 |
| ▸ | AR | P10275 | 1/20 | 0.75 |
| ▸ | MEN1 | O00255 | 6/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.72 |
| ▸ | TP53 | P04637 | 1/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.71 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.68 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1638707 | 1.00 | KDM4E (0.79) | KDM4EKMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL4447019 | 1.00 | KDM4E (0.79) | KDM4EKMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL683812 | 0.91 | KDM4E (0.77) | KDM4EKMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL26974362 | 0.90 | PGR (0.76) | KDM4EKMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL685201 | 0.88 | KDM4E (1.00) | KDM4EKMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL684521 | 0.88 | KDM4E (0.74) | KDM4EKMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL16271241 | 0.86 | AR (1.00) | KDM4EKMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL22179538 | 0.85 | KDM4E (0.69) | KDM4EKMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL22179608 | 0.85 | PIK3CG (0.73) | KDM4EKMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL684930 | 0.85 | KMT2A (0.76) | KDM4EKMT2AMAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098309-A1 | METHODS OF INHIBITING THE FORMATION OF AMYLOID-BETA DIFFUSABLE LIGANDS USING ACYLHYDRAZIDE COMPOUNDS | ACUMEN PHARMACEUTICALS, INC. (US) | 2011-04-28 | — | — | US | disclosed |
| EP-2194975-A2 | METHODS OF INHIBITING THE FORMATION OF AMYLOID-ß DIFFUSABLE LIGANDS USING A ACYLHYDRAZIDE COMPOUNDS | Acumen Pharmaceuticals, Inc. (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009009768-A2 | METHODS OF INHIBITING THE FORMATION OF AMYLOID-β DIFFUSABLE LIGANDS USING A ACYLHYDRAZIDE COMPOUDS | ACUMEN PHARMACEUTICALS, INC. (US) | 2009-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098309-A1 | METHODS OF INHIBITING THE FORMATION OF AMYLOID-BETA DIFFUSABLE LIGANDS USING ACYLHYDRAZIDE COMPOUNDS | APP, APBA1, BACE1 | KDM4E 4638/4885KMT2A 3625/4885MAPT 85/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.