Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SSTR3 | P32745 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12448915 | 0.92 | PRMT5 (0.49) | PRMT5WDR77SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL16250586 | 0.88 | MAPK1 (0.41) | PRMT5WDR77SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL15054703 | 0.87 | PRMT5 (0.57) | PRMT5WDR77SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3633900 | 0.78 | KDM1A (0.48) | PRMT5WDR77CCNT1POLBSSTR3 | |
| SCHEMBL4980744 | 0.78 | PRMT5 (0.64) | PRMT5WDR77SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5760854 | 0.76 | KCNH2 (0.46) | PRMT5WDR77SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL951983 | 0.75 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3KDM1ACYP2D6 | |
| SCHEMBL951982 | 0.75 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3KDM1ACYP2D6 | |
| SCHEMBL5763787 | 0.75 | HTT (0.51) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL16250572 | 0.74 | HRH3 (0.38) | PRMT5WDR77CCNT1POLBKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2404907-B1 | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC (US) | 2015-01-14 | — | — | EP | disclosed |