Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid SCHEMBL7487538 | 0.89 | DPP4 (0.44) | KDM1AMAOBCCNT1POLBHTR6 | |
| SCHEMBL16250572 | 0.86 | HRH3 (0.38) | KDM1AMAOBCCNT1POLBHRH3 | |
| SCHEMBL16463547 | 0.86 | SOS1 (0.39) | KDM1AMAOBCCNT1POLBHTR6 | |
| SCHEMBL12448915 | 0.86 | PRMT5 (0.49) | CCNT1POLBHRH3CDK9PRMT5 | |
| SCHEMBL20767323 | 0.84 | KDM1A (0.46) | KDM1AMAOBCCNT1HTR6DPP4 | |
| SCHEMBL3633946 | 0.83 | ALDH1A1 (0.39) | KDM1AMAOBPOLBHRH3DPP4 | |
| SCHEMBL3355681 | 0.81 | BCHE (0.54) | KDM1AMAOBPOLBHRH3MEN1 | |
| SCHEMBL375105 | 0.81 | KDM1A (0.48) | KDM1APOLBHRH3MEN1RAB9A | |
| SCHEMBL16465008 | 0.81 | POLB (0.45) | KDM1APOLBHTR6HRH3MEN1 | |
| SCHEMBL16463498 | 0.81 | POLB (0.45) | KDM1AMAOBPOLBHTR6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148879-A1 | THIA(DIA)ZOLES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | Janssen Pharmaceutica, N.V. (BE) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008128996-A1 | THIA(DIA)ZOLES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-10-30 | — | — | WO | disclosed |
| EP-1299357-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2003-04-09 | — | — | EP | disclosed |
| WO-2001098273-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-12-27 | — | — | WO | disclosed |