Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 10/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | GRK2 | P25098 | 9/20 | 0.38 |
| ▸ | GRK5 | P34947 | 9/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2680988 | 0.88 | MET (0.51) | METNTRK1GRK2GRK5ALK | |
| SCHEMBL2681137 | 0.79 | GRK5 (0.57) | METGRK2GRK5ALKFLT3 | |
| SCHEMBL2682349 | 0.75 | MET (0.59) | METNTRK1GRK2GRK5ALK | |
| SCHEMBL18472791 | 0.74 | MET (0.57) | METNTRK1GRK2GRK5FGFR1 | |
| SCHEMBL18427715 | 0.73 | MET (0.54) | METGRK2GRK5FGFR1FGFR2 | |
| SCHEMBL4096428 | 0.73 | EGFR (0.71) | METEGFRNTRK1FGFR1FGFR2 | |
| SCHEMBL2681319 | 0.71 | FGFR1 (0.57) | METEGFRGRK2GRK5FGFR1 | |
| SCHEMBL2680623 | 0.71 | FYN (0.48) | METFGFR1KDR | |
| SCHEMBL2681889 | 0.70 | MET (0.53) | METGRK2GRK5FGFR1FGFR2 | |
| SCHEMBL2682031 | 0.69 | GRK5 (0.60) | METNTRK1GRK2GRK5ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454253-B1 | AMINOPYRIDINE DERIVATIVES FOR TREATING TUMORS AND INFLAMMATORY DISEASES | MERCK PATENT GMBH (DE) | 2015-01-21 | — | — | EP | disclosed |