Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 17/20 | 0.45 |
| ▸ | F11 | P03951 | 11/20 | 0.43 |
| ▸ | TPSB2 | P20231 | 9/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.41 |
| ▸ | PLG | P00747 | 2/20 | 0.41 |
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | F7 | P08709 | 2/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | F9 | P00740 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17764260 | 0.94 | CFD (0.39) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL16410248 | 0.94 | CFD (0.39) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL17764337 | 0.93 | CFD (0.44) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL16397316 | 0.93 | CFD (0.45) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL17764247 | 0.92 | CFD (0.44) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL16397339 | 0.92 | CFD (0.44) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL16397335 | 0.90 | CFD (0.48) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL16397406 | 0.90 | CFD (0.44) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL17764424 | 0.89 | CFD (0.44) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL17764318 | 0.89 | CFD (0.43) | CFDF11TPSB2KLKB1PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022182-A1 | AMINOMETHYL-BIARYL DERIVATIVES AS COMPLEMENT FACTOR D INHIBITORS AND USES THEREOF | Novartis AG (CH) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015009977-A1 | AMINOMETHYL-BIARYL DERIVATIVES AS COMPLEMENT FACTOR D INHIBITORS AND USES THEREOF | NOVARTIS AG (CH) | 2015-01-22 | — | — | WO | disclosed |