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Sugi Predict / Targets / CFD

CFD

Complement factor D · P00746 · CFD on Sugi Atlas →

53,921 patent compounds predicted against CFD, 29,173 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Trimazosin Trimazosin (SCHEMBL113671) 0.54 17/20
Trimazosin Trimazosin (SCHEMBL122583) 0.53 17/20
SCHEMBL845332 SCHEMBL845332 0.42 7/20
SCHEMBL1045204 SCHEMBL1045204 0.36 7/20
SCHEMBL1045205 SCHEMBL1045205 0.36 7/20
SCHEMBL1007508 SCHEMBL1007508 0.68 6/20
SCHEMBL172996 SCHEMBL172996 0.61 6/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL559390) 0.45 6/20
SCHEMBL1104875 SCHEMBL1104875 0.36 6/20
SCHEMBL1300764 SCHEMBL1300764 0.33 6/20
SCHEMBL1300777 SCHEMBL1300777 0.33 6/20
SCHEMBL172995 SCHEMBL172995 0.56 5/20
SCHEMBL960144 SCHEMBL960144 0.53 5/20
SCHEMBL762013 SCHEMBL762013 0.46 5/20
SCHEMBL1043496 SCHEMBL1043496 0.37 5/20
SCHEMBL1375477 SCHEMBL1375477 0.37 5/20
SCHEMBL1372946 SCHEMBL1372946 0.36 5/20
SCHEMBL1045792 SCHEMBL1045792 0.35 5/20
SCHEMBL1045793 SCHEMBL1045793 0.35 5/20
SCHEMBL1046014 SCHEMBL1046014 0.34 5/20

Clinical trials — most relevant to CFD by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Efficacy and Safety of Fanhdi®, a High-purity Von Willebrand Containing FVIII Concentrate, in Pediatric Patients With Von Willebrand Disease PHASE4WITHDRAWN
Rituximab Treatment to Block HLA Antibodies in Renal Transplant Recipients PHASE1/PHASE2WITHDRAWN
Study of Plasma Exchange in Severe COVID-19 PHASE2COMPLETED
Palomid 529 in Patients With Neovascular Age-Related Macular Degeneration PHASE1COMPLETED
Eculizumab Therapy for Dense Deposit Disease and C3 Nephropathy PHASE1COMPLETED
Recombinant Human Mannose-Binding Lectin (MBL) in Treating Young Patients With MBL Deficiency and Fever and Neutropenia PHASE1WITHDRAWN
TP10 Use in Patients With C3 Glomerulopathy (C3G) PHASE1WITHDRAWN
Complement Factor H Haplotypes and Smoking in Age-related Macular Degeneration nanCOMPLETED
Platelets and Complement Activation in Coronary Artery Bypass Graft Surgery (CABG) nanCOMPLETED
Genetic Analysis of Chronic Central Serous Chorioretinopathy Masquerading as Neovascular AMD nanCOMPLETED
DKK-3 rs11544814 and CFH rs10737680 Polymorphism and Protein Levels With Non Surgical Periodontal Therapy in Periodontitis Patients With and Without CAD nanUNKNOWN
Association of Macular Pigment Optical Density (MPOD) and Genetic Variants in Complement Factor H in Subjects With Choroidal Neovascular (CNV) nanCOMPLETED
ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders nanRECRUITING
Genetic Load and Phenotype in Aggressive AMD nanCOMPLETED
Study of Genetic Anomalies of Complement Related Proteins in Patients With IgA Glomerulonephritis nanCOMPLETED
Assessment of Whole Blood Cold Stored Platelets nanCOMPLETED
Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests nanUNKNOWN
Proadrenomedullin for Early Risk Assessment in the Emergency Department nanCOMPLETED
Genetic Biomarkers for the Response to Anti-VEGF (Vascular Endothelial Growth Factor).Treatment in Wet Age-related Macular Degeneration (Wet ARMD) nanCOMPLETED
Evaluation of Interleukine 6 (and Other Cytokines and Inflammatory Markers) in COVID-19 Patients With a Systemic Inflammatory Response Syndrome nanCOMPLETED
Role of Renal Artery Doppler in Critically Ill Children With Acute Kidney Injury nanUNKNOWN
Complement C5a Receptors in Hidradenitis Suppurativa nanCOMPLETED
Assessment of Disease Severity, Progression and Treatment in Infected Patients Presenting to the Emergency Department nanCOMPLETED
Immune System in Diabetic Kidney Disease nanENROLLING_BY_INVITATION
Procedure Outcome Predictor (POP) Using the Complement Cascade nanCOMPLETED
Multicentric Prospective Study of Genetic and Physiopathology Concerning Dysregulation of Complement During Repeated Fetal Abortions nanCOMPLETED
VOCs in Kidney and Liver Transplants nanUNKNOWN
Complement Activation in the Lysosomal Storage Disorders nanWITHDRAWN
Complement and Graft-versus-host Disease nanCOMPLETED
Does Complement Factor H Gene Polymorphism Play a Role in the Regulation of Vascular Tone in the Choroid? nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a CFD binder may also engage these)

ProteinNameSimilarity
P51779 — 0.999 P51779 →
Q3T0A3 — 0.995 Q3T0A3 →
P32038 — 0.988 P32038 →
P03953 — 0.983 P03953 →
P20160 — 0.975 P20160 →
TPSAB1 Tryptase beta-1 0.975 landscape →
TPSB2 Tryptase beta-2 0.974 landscape →
Q9H2R5 — 0.972 Q9H2R5 →
Q80WM7 — 0.971 Q80WM7 →
Q8NF86 — 0.969 Q8NF86 →
Q7JIG6 — 0.968 Q7JIG6 →
Q14B24 — 0.967 Q14B24 →
P51124 — 0.966 P51124 →
KLK6 Kallikrein-6 0.965 landscape →
P22457 — 0.965 P22457 →
Q9XSM2 — 0.965 Q9XSM2 →
P21845 — 0.964 P21845 →
P80015 — 0.963 P80015 →
KLK2 Kallikrein-2 0.962 landscape →
Q03238 — 0.962 Q03238 →
P12323 — 0.962 P12323 →
O43240 — 0.961 O43240 →
Q00356 — 0.960 Q00356 →
KLK13 Kallikrein-13 0.960 landscape →
Q28773 — 0.960 Q28773 →
Q07276 — 0.960 Q07276 →
KLK3 Prostate-specific antigen 0.960 landscape →
Q6IE59 — 0.960 Q6IE59 →
Q9UKR0 — 0.960 Q9UKR0 →
P35034 — 0.960 P35034 →