Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.48 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | P4HB | P07237 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16399350 | 1.00 | NFE2L2 (0.48) | NFE2L2FBP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL17969016 | 0.88 | NFE2L2 (0.45) | NFE2L2FBP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL16398906 | 0.88 | NFE2L2 (0.45) | NFE2L2FBP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL18003166 | 0.82 | NFE2L2 (0.49) | NFE2L2FBP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL26425426 | 0.81 | NFE2L2 (0.47) | NFE2L2FBP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL18002944 | 0.77 | NFE2L2 (0.54) | NFE2L2FBP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL16399341 | 0.77 | NFE2L2 (0.54) | NFE2L2FBP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL16399338 | 0.77 | NFE2L2 (0.54) | NFE2L2FBP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL18002652 | 0.76 | NFE2L2 (0.62) | NFE2L2FBP1MAOBL3MBTL1ALDH1A1 | |
| SCHEMBL18002626 | 0.76 | NFE2L2 (0.52) | NFE2L2FBP1CHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022199-A1 | CYANOTRIAZOLE COMPOUNDS | Otsuka Pharmaceutical Co., Ltd. (JP) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015008872-A1 | CYANOTRIAZOLE COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2015-01-22 | — | — | WO | disclosed |