SCHEMBL16401310

SCHEMBL16401310

Cc1cccc(C)c1NC(=O)NS/N=C/c1ccc2c(c1)CCc1c(-c3ccc(OC(F)(F)F)cc3)noc1-2

nearest known ligand 0.41

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
SMURF2 Q9HAU4 6/20 0.41
SMURF1 Q9HCE7 6/20 0.41
TP53 P04637 1/20 0.37
CYP1A2 P05177 1/20 0.35
CYP2D6 P10635 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
TRPV1 Q8NER1 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16401571 0.94 SMURF2 (0.39) SMURF2SMURF1
SCHEMBL16400284 0.87 SMURF2 (0.36) SMURF2SMURF1TP53TRPV1
SCHEMBL16401266 0.86 SMURF2 (0.40) SMURF2SMURF1TP53
SCHEMBL16401160 0.85 TRPV1 (0.33) TRPV1
SCHEMBL16401142 0.85 MAPT (0.34) SMURF2SMURF1TRPV1
SCHEMBL16400718 0.84 SMURF2 (0.36) SMURF2SMURF1TP53
SCHEMBL16401312 0.83 LMNA (0.44) SMURF2SMURF1TP53CYP1A2CYP2D6
SCHEMBL16401314 0.83 LMNA (0.44) SMURF2SMURF1TP53CYP1A2CYP2D6
SCHEMBL16401018 0.83 MAPT (0.37) SMURF2SMURF1TP53SMN1; SMN2
SCHEMBL16401040 0.81 TRPV1 (0.36) SMURF2SMURF1TP53CYP2D6TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3022185-B1 PESTICIDE COMPOUNDS BASF SE (DE) 2017-09-06 EP disclosed
US-9497970-B2 Pesticide compounds BASF SE (DE) 2016-11-22 US disclosed
US-20160157491-A1 Pesticide Compounds BASF SE (DE) 2016-06-09 US disclosed
EP-3022185-A1 PESTICIDE COMPOUNDS BASF SE (DE) 2016-05-25 EP disclosed
WO-2015007682-A1 PESTICIDE COMPOUNDS BASF SE (DE) 2015-01-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160157491-A1 Pesticide Compounds C1R, C1S, CBR3 SMURF2 3631/4885SMURF1 3269/4885TP53 4116/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.