SCHEMBL16401337

SCHEMBL16401337

COC(=O)c1ccc(CCN2C(=O)CCC2CO)cc1

nearest known ligand 0.49

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 10/20 0.49
PTGER2 P43116 9/20 0.49
PTGER3 P43115 3/20 0.49
CYP4A11 Q02928 2/20 0.48
CYP4F2 P78329 1/20 0.47
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
ALDH1A1 P00352 1/20 0.43
IDH1 O75874 1/20 0.43
KDM4E B2RXH2 1/20 0.42
LOXL2 Q9Y4K0 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4946290 1.00 PTGER4 (0.49) PTGER4PTGER2PTGER3CYP4A11CYP4F2
SCHEMBL4690241 0.93 CYP4A11 (0.52) PTGER4PTGER2PTGER3CYP4A11CYP4F2
SCHEMBL4940026 0.93 CYP4A11 (0.49) PTGER4PTGER2PTGER3CYP4A11CYP4F2
SCHEMBL19513647 0.91 PTGER4 (0.53) PTGER4PTGER2PTGER3CYP4A11CYP4F2
SCHEMBL5733032 0.88 PTGER4 (0.50) PTGER4PTGER2PTGER3MEN1KMT2A
SCHEMBL19513757 0.85 PTGER4 (0.47) PTGER4PTGER2PTGER3CYP4A11CYP4F2
SCHEMBL16400877 0.85 PTGER4 (0.64) PTGER4PTGER2PTGER3
SCHEMBL17475054 0.83 PTGER4 (0.56) PTGER4PTGER2PTGER3ALDH1A1
SCHEMBL4690002 0.83 ALDH1A1 (0.54) PTGER4PTGER2PTGER3CYP4A11CYP4F2
SCHEMBL4691930 0.83 PTGER4 (0.56) PTGER4PTGER2PTGER3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10729810-B2 Methods, systems, and compositions for promoting bone growth CAYMAN CHEMICAL COMPANY, INC (US) 2020-08-04 US disclosed
EP-3235817-B1 LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS CAYMAN CHEMICAL CO INC (US) 2018-12-12 EP disclosed
EP-3235817-A1 LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS Cayman Chemical Company, Incorporated (US) 2017-10-25 EP disclosed
US-9688627-B2 Lactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions CAYMAN CHEMICAL COMPANY, INC. (US) 2017-06-27 US disclosed
US-9676712-B2 Lactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions CAYMAN CHEMICAL COMPANY, INC. (US) 2017-06-13 US disclosed
EP-2989098-B1 LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS CAYMAN CHEMICAL CO INC (US) 2017-05-10 EP disclosed
EP-2989098-B1 LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS CAYMAN CHEMICAL CO INC (US) 2017-05-10 EP disclosed
US-20160158413-A1 METHODS, SYSTEMS, AND COMPOSITIONS FOR PROMOTING BONE GROWTH CAYMAN CHEMICAL COMPANY, INC. (US) 2016-06-09 US disclosed
EP-3021879-A2 METHODS, SYSTEMS, AND COMPOSITIONS FOR PROMOTING BONE GROWTH Cayman Chemical Company, Incorporated (US) 2016-05-25 EP disclosed
US-20160060216-A1 LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS CAYMAN CHEMICAL COMPANY, INCORPORATED 2016-03-03 US disclosed
US-20160031811-A1 LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS CAYMAN CHEMICAL COMPANY, INCORPORATED 2016-02-04 US disclosed
WO-2015009991-A2 METHODS, SYSTEMS, AND COMPOSITIONS FOR PROMOTING BONE GROWTH CAYMAN CHEMICAL COMPANY, INC. (US) 2015-01-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160031811-A1 LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS PTGER4, PTGER1, PTGER3 PTGER4 1/4885PTGER2 4/4885PTGER3 3/4885
US-20160060216-A1 LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS PTGER4, PTGER1, PTGER3 PTGER4 1/4885PTGER2 4/4885PTGER3 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.