Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.53 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.53 |
| ▸ | IL2 | P60568 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 6/20 | 0.47 |
| ▸ | EGFR | P00533 | 5/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 6/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12726468 | 0.90 | ABL1 (0.47) | BRAFPKMYT1EGFRSRCPRKD3 | |
| SCHEMBL12726212 | 0.88 | BRAF (0.58) | BRAFPKMYT1IGF1REGFRERBB2 | |
| SCHEMBL1641719 | 0.84 | ABL1 (0.59) | BRAFEGFRSRCPRKD3GSK3B | |
| SCHEMBL12726205 | 0.81 | SLC2A1 (0.67) | BRAFPKMYT1IGF1REGFRERBB2 | |
| SCHEMBL1641693 | 0.81 | BRAF (0.54) | BRAFPKMYT1IGF1REGFRERBB2 | |
| SCHEMBL12726216 | 0.81 | BRAF (0.52) | BRAFPKMYT1IGF1REGFRERBB2 | |
| SCHEMBL1641187 | 0.81 | ABL1 (0.43) | BRAFEGFRAURKAKDRAURKB | |
| SCHEMBL3442631 | 0.80 | SLC2A1 (0.71) | BRAFPKMYT1IGF1REGFRERBB2 | |
| SCHEMBL1641738 | 0.80 | IGF1R (0.69) | BRAFPKMYT1IGF1REGFRERBB2 | |
| SCHEMBL1641934 | 0.80 | SLC2A1 (0.56) | BRAFPKMYT1IGF1REGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098296-A1 | Thiazole And Oxazole Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2011-04-28 | — | — | US | disclosed |
| US-20110098296-A1 | Thiazole And Oxazole Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2011-04-28 | — | — | US | disclosed |
| WO-2009076140-A1 | THIAZOLE AND OXAZOLE KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098296-A1 | Thiazole And Oxazole Kinase Inhibitors | PDXK, MAP3K1, MAP4K2 | BRAF 151/4885PKMYT1 485/4885IL2 3632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.