Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE6D | O43924 | 5/20 | 0.73 |
| ▸ | PDE6A | P16499 | 5/20 | 0.73 |
| ▸ | PDE6G | P18545 | 5/20 | 0.73 |
| ▸ | PDE6B | P35913 | 5/20 | 0.73 |
| ▸ | PDE6C | P51160 | 5/20 | 0.73 |
| ▸ | PDE6H | Q13956 | 5/20 | 0.73 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16395534 | 0.92 | PDE6D (0.73) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL16395658 | 0.89 | PDE6D (0.78) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL16395228 | 0.85 | PDE6D (0.85) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL16405986 | 0.85 | PDE6D (0.85) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL16394991 | 0.85 | PDE6D (1.00) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL16395338 | 0.84 | PDE6D (0.61) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL16405990 | 0.84 | PDE6D (0.82) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL16395164 | 0.83 | PDE6D (1.00) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL16395288 | 0.82 | PDE6D (0.81) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL16405997 | 0.81 | PDE6D (0.80) | PDE6DPDE6APDE6GPDE6BPDE6C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3021947-A1 | AZAINDOLE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING THE SAME | Global Alliance For Tb Drug Development (US) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015009525-A1 | AZAINDOLE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING THE SAME | GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT (US) | 2015-01-22 | — | — | WO | disclosed |