Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE6D | O43924 | 5/20 | 0.85 |
| ▸ | PDE6A | P16499 | 5/20 | 0.85 |
| ▸ | PDE6G | P18545 | 5/20 | 0.85 |
| ▸ | PDE6B | P35913 | 5/20 | 0.85 |
| ▸ | PDE6C | P51160 | 5/20 | 0.85 |
| ▸ | PDE6H | Q13956 | 5/20 | 0.85 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16395228 | 0.93 | PDE6D (0.85) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL16395288 | 0.92 | PDE6D (0.81) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL16394991 | 0.92 | PDE6D (1.00) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL16405997 | 0.91 | PDE6D (0.80) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL16405990 | 0.91 | PDE6D (0.82) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL19264838 | 0.91 | PDE6D (0.79) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL16395658 | 0.89 | PDE6D (0.78) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL19264859 | 0.87 | PDE6D (0.79) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL16395164 | 0.86 | PDE6D (1.00) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL16395469 | 0.86 | PDE6D (0.86) | PDE6DPDE6APDE6GPDE6BPDE6C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3021947-B1 | AZAINDOLE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING THE SAME | GLOBAL ALLIANCE FOR TB DRUG DEV (US) | 2017-08-23 | — | — | EP | disclosed |
| EP-3021947-B1 | AZAINDOLE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING THE SAME | GLOBAL ALLIANCE FOR TB DRUG DEV (US) | 2017-08-23 | — | — | EP | disclosed |
| US-9163020-B2 | Azaindole compounds, synthesis thereof, and methods of using the same | GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT (US) | 2015-10-20 | — | — | US | disclosed |
| US-9163020-B2 | Azaindole compounds, synthesis thereof, and methods of using the same | GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT (US) | 2015-10-20 | — | — | US | disclosed |
| US-20150025087-A1 | AZAINDOLE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING THE SAME | FOUNDATION FOR NEGLECTED DISEASE RESEARCH (IN) | 2015-01-22 | — | — | US | disclosed |
| US-20150025087-A1 | AZAINDOLE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING THE SAME | FOUNDATION FOR NEGLECTED DISEASE RESEARCH (IN) | 2015-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150025087-A1 | AZAINDOLE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING THE SAME | DPEP1, QDPR, IDO1 | PDE6D 3468/4885PDE6A 2102/4885PDE6G 2734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.