Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19050133 | 0.88 | SMN1; SMN2 (0.78) | SMN1; SMN2KDM4EALDH1A1GAAHTT | |
| SCHEMBL30531213 | 0.85 | SMN1; SMN2 (0.73) | SMN1; SMN2KDM4EALDH1A1GAAKMT2A | |
| SCHEMBL28596962 | 0.85 | SMN1; SMN2 (0.73) | SMN1; SMN2KDM4EALDH1A1GAAKMT2A | |
| SCHEMBL7598160 | 0.82 | KDM4E (0.69) | SMN1; SMN2KDM4EALDH1A1GAAHTT | |
| SCHEMBL30531237 | 0.82 | KDM4E (0.69) | SMN1; SMN2KDM4EALDH1A1GAAHTT | |
| Potassium Ion SCHEMBL9491461 | 0.80 | SMN1; SMN2 (0.67) | SMN1; SMN2KDM4EALDH1A1HTTMEN1 | |
| SCHEMBL1641286 | 0.80 | SMN1; SMN2 (0.69) | SMN1; SMN2KDM4EALDH1A1GAAHTT | |
| SCHEMBL70795 | 0.79 | SMN1; SMN2 (0.65) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL31128381 | 0.78 | SMN1; SMN2 (0.63) | SMN1; SMN2KDM4EALDH1A1GAAHTT | |
| SCHEMBL9491457 | 0.77 | SMN1; SMN2 (0.62) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101787018-A | 2,6-dimethyl 3,5-bis-[4,4'-(2-amino-3-cyano-thiophene)] pyridine and synthetic method thereof | UNIV SHANGHAI | 2010-07-28 | — | — | CN | claimed |
| US-6176909-B1 | IN POLYMERIC BINDER | XEROX CORPORATION | 2001-01-23 | — | — | US | claimed |
| CN-113173884-B | Method for synthesizing pyridine and derivative thereof by catalyzing hans ester 1, 4-dihydropyridine compound with titanocene dichloride | 陕西师范大学 | 2023-08-15 | — | — | CN | disclosed |
| US-8273767-B2 | Bicyclic-substituted amines as histamine-3 receptor ligands | ABBOTT LABORATORIES (US) | 2012-09-25 | — | — | US | disclosed |
| CN-101787018-B | 2,6-dimethyl 3,5-bis-[4,4'-(2-amino-3-cyano-thiophene)] pyridine and synthetic method thereof | UNIV SHANGHAI | 2012-01-04 | — | — | CN | disclosed |
| US-7947711-B2 | Bicyclic-substituted amines as histamine-3 receptor ligands | ABBOTT LABORATORIES (US) | 2011-05-24 | — | — | US | disclosed |
| US-20110098285-A1 | BICYCLIC-SUBSTITUTED AMINES AS HISTAMINE-3 RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2011-04-28 | — | — | US | disclosed |
| CN-101787018-A | 2,6-dimethyl 3,5-bis-[4,4'-(2-amino-3-cyano-thiophene)] pyridine and synthetic method thereof | UNIV SHANGHAI | 2010-07-28 | — | — | CN | disclosed |
| US-20090054420-A1 | BICYCLIC-SUBSTITUTED AMINES AS HISTAMINE-3 RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2009-02-26 | — | — | US | disclosed |
| US-7456196-B2 | Bicyclic-substituted amines as histamine-3 receptor ligands | ABBOTT LABORATORIES (US) | 2008-11-25 | — | — | US | disclosed |
| CN-1948287-A | Acetyl-2,6-dimethyl pyridine-3,5-diethyl ketone hydrazone and its synthesis method | UNIV SHANGHAI (CN) | 2007-04-18 | — | — | CN | disclosed |
| CN-1948289-A | Phenacyl-2,6-dimethyl pyridine-3,5-diethylketone hydrazone and its synthesis method | UNIV SHANGHAI (CN) | 2007-04-18 | — | — | CN | disclosed |
| US-20070072096-A1 | Negative curable dye-containing composition, color filter, and method of manufacturing the same | FUJI PHOTO FILM CO., LTD. | 2007-03-29 | — | — | US | disclosed |
| US-7153889-B2 | Bicyclic-substituted amines as histamine-3 receptor ligands | ABBOTT LABORATORIES (US) | 2006-12-26 | — | — | US | disclosed |
| US-20060194798-A1 | Bicyclic-substituted amines as histamine-3 receptor ligands | ABBVIE INC. | 2006-08-31 | — | — | US | disclosed |
| EP-1569637-A1 | BICYCLIC-SUBSTITUTED AMINES AS HISTAMINE-3 RECEPTOR LIGANDS | Abbott Laboratories (US) | 2005-09-07 | — | — | EP | disclosed |
| US-20040152704-A1 | Bicyclic-substituted amines as histamine-3 receptor ligands | ABBVIE INC. | 2004-08-05 | — | — | US | disclosed |
| WO-2004043458-A1 | BICYCLIC-SUBSTITUTED AMINES AS HISTAMINE-3 RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2004-05-27 | — | — | WO | disclosed |
| US-20020045679-A1 | Aqueous ink composition | HITACHI MAXELL, LTD. (JP) | 2002-04-18 | — | — | US | disclosed |
| US-6176909-B1 | IN POLYMERIC BINDER | XEROX CORPORATION | 2001-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098285-A1 | BICYCLIC-SUBSTITUTED AMINES AS HISTAMINE-3 RECEPTOR LIGANDS | HRH3, HRH4, HRH2 | SMN1; SMN2 3418/4885KDM4E 3344/4885ALDH1A1 1183/4885 |
| US-20060194798-A1 | Bicyclic-substituted amines as histamine-3 receptor ligands | HRH3, HRH4, HRH2 | SMN1; SMN2 3418/4885KDM4E 3344/4885ALDH1A1 1183/4885 |
| US-20090054420-A1 | BICYCLIC-SUBSTITUTED AMINES AS HISTAMINE-3 RECEPTOR LIGANDS | HRH3, HRH4, HRH2 | SMN1; SMN2 3418/4885KDM4E 3344/4885ALDH1A1 1183/4885 |
| US-20040152704-A1 | Bicyclic-substituted amines as histamine-3 receptor ligands | HRH3, HRH4, HRH1 | SMN1; SMN2 3393/4885KDM4E 3614/4885ALDH1A1 687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.