Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 13/20 | 0.50 |
| ▸ | RAB9A | P51151 | 13/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | STAT1 | P42224 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.47 |
| ▸ | RELA | Q04206 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16403953 | 0.88 | NPC1 (0.47) | NPC1RAB9AMEN1KMT2AMAPK1 | |
| SCHEMBL16403951 | 0.88 | RAB9A (0.47) | NPC1RAB9AMEN1KMT2AMAPK1 | |
| SCHEMBL14315443 | 0.86 | RAB9A (0.63) | NPC1RAB9AMEN1KMT2AMAPK1 | |
| SCHEMBL16403962 | 0.86 | NPC1 (0.49) | NPC1RAB9AMEN1KMT2AMAPK1 | |
| SCHEMBL16403975 | 0.85 | NPC1 (0.69) | NPC1RAB9AMEN1KMT2AMAPK1 | |
| SCHEMBL16403947 | 0.85 | CA12 (0.49) | NPC1RAB9AMEN1KMT2AMAPK1 | |
| SCHEMBL14315442 | 0.85 | NPC1 (0.53) | NPC1RAB9AMEN1KMT2AMAPK1 | |
| SCHEMBL16403943 | 0.84 | RAB9A (0.47) | NPC1RAB9AMEN1KMT2AMAPK1 | |
| SCHEMBL14317616 | 0.84 | NPC1 (0.52) | NPC1RAB9AMEN1KMT2AMAPK1 | |
| SCHEMBL16403950 | 0.84 | RAB9A (0.52) | NPC1RAB9AMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |