Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 16/20 | 0.79 |
| ▸ | AR | P10275 | 15/20 | 0.79 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.47 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SHBG | P04278 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12924053 | 0.88 | AR (1.00) | PGRARNR3C2 | |
| SCHEMBL12923989 | 0.88 | AR (1.00) | PGRARNR3C2 | |
| SCHEMBL16404180 | 0.86 | PGR (0.78) | PGRARNR1I2NR3C2SLC6A4 | |
| SCHEMBL16404175 | 0.86 | PGR (0.78) | PGRARNR3C2 | |
| SCHEMBL12924013 | 0.86 | AR (0.83) | PGRARNR3C2 | |
| SCHEMBL13013654 | 0.84 | AR (0.58) | PGRARNR1I2NR3C2SLC6A4 | |
| SCHEMBL12906943 | 0.82 | PGR (0.53) | PGRARNR1I2NR3C2SLC6A4 | |
| SCHEMBL16404187 | 0.82 | PGR (0.57) | PGRARNR1I2NR3C2SLC6A4 | |
| SCHEMBL16404186 | 0.81 | PGR (0.81) | PGRARNR1I2NR3C2SLC6A4 | |
| SCHEMBL16404185 | 0.80 | AR (0.78) | PGRARNR1I2NR3C2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937058-B2 | 17-hydroxy-19-nor-21-carboxylic acid-steroid γ-lactone derivative, use thereof, and medicament containing the derivative | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-01-20 | — | — | US | disclosed |