Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 13/20 | 0.59 |
| ▸ | HTR2C | P28335 | 13/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.58 |
| ▸ | CNR1 | P21554 | 2/20 | 0.53 |
| ▸ | CNR2 | P34972 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5999099 | 0.87 | CNR1 (0.65) | HTR2AHTR2CSLC6A4CNR1CNR2 | |
| SCHEMBL16404246 | 0.84 | CNR1 (0.61) | HTR2AHTR2CSLC6A4CNR1CNR2 | |
| SCHEMBL2681412 | 0.75 | HTR2A (1.00) | HTR2AHTR2CSLC6A4HTR1ADRD2 | |
| SCHEMBL16404225 | 0.75 | CNR2 (0.56) | CNR1CNR2MEN1NPC1LMNA | |
| SCHEMBL16404230 | 0.74 | CNR2 (0.66) | CNR1CNR2MAPK14MEN1NPC1 | |
| SCHEMBL1080194 | 0.74 | HTR2A (1.00) | HTR2AHTR2CSLC6A4HTR1ADRD2 | |
| SCHEMBL1050475 | 0.72 | HTR2A (0.83) | HTR2AHTR2CSLC6A4 | |
| SCHEMBL16404204 | 0.71 | CNR1 (0.67) | CNR1CNR2NPC1MAPTHPGD | |
| SCHEMBL16404206 | 0.70 | CNR1 (0.60) | HTR2AHTR2CSLC6A4CNR1CNR2 | |
| SCHEMBL665304 | 0.70 | MEN1 (0.69) | MEN1NPC1LMNAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937184-B2 | 1H-imidazole derivatives as cannabinoid CB2 receptor modulators | ABBVIE B.V. (NL) | 2015-01-20 | — | — | US | disclosed |
| US-8937184-B2 | 1H-imidazole derivatives as cannabinoid CB2 receptor modulators | ABBVIE B.V. (NL) | 2015-01-20 | — | — | US | disclosed |