Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.48 |
| ▸ | THRA | P10827 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6847142 | 0.89 | GAA (0.52) | GAATSHRPLOD2GRM2HDAC1 | |
| SCHEMBL13562605 | 0.86 | GAA (0.52) | GAATSHRPLOD2HDAC1HDAC8 | |
| SCHEMBL6847648 | 0.86 | THRA (0.52) | PLOD2THRATHRBL3MBTL1HDAC1 | |
| SCHEMBL13562607 | 0.84 | THRA (0.49) | TSHRPLOD2THRATHRBL3MBTL1 | |
| SCHEMBL13562685 | 0.81 | KMT2A (0.56) | GAATSHRPLOD2HDAC1HDAC8 | |
| SCHEMBL6847797 | 0.79 | THRA (0.55) | THRATHRBL3MBTL1HDAC1HDAC8 | |
| SCHEMBL13562457 | 0.78 | GAA (0.51) | GAATSHRPLOD2GRM2HDAC1 | |
| SCHEMBL13562667 | 0.78 | GAA (0.51) | GAATSHRPLOD2HDAC1HDAC8 | |
| SCHEMBL552456 | 0.77 | HDAC1 (0.63) | GAATSHRPLOD2L3MBTL1HDAC1 | |
| SCHEMBL31030252 | 0.77 | HDAC1 (0.63) | GAATSHRPLOD2L3MBTL1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937091-B2 | Inhibitor of protein crosslinking and use of the same | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2015-01-20 | — | — | US | disclosed |
| US-8937091-B2 | Inhibitor of protein crosslinking and use of the same | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2015-01-20 | — | — | US | disclosed |