Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 5/20 | 0.35 |
| ▸ | BACE1 | P56817 | 4/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16404439 | 0.93 | EPHX2 (0.36) | BDKRB1BACE1HTTPOLB | |
| SCHEMBL16404397 | 0.92 | BDKRB1 (0.38) | BDKRB1BACE1ROCK2CNR1 | |
| SCHEMBL16404394 | 0.92 | BDKRB1 (0.39) | BDKRB1BACE1HTTPOLB | |
| SCHEMBL10071170 | 0.91 | EPHX2 (0.38) | BDKRB1CNR1 | |
| SCHEMBL16404402 | 0.91 | BDKRB1 (0.35) | BDKRB1BACE1ROCK2HTTKCNH2 | |
| SCHEMBL16404423 | 0.89 | BDKRB1 (0.34) | BDKRB1BACE1HTTPOLB | |
| SCHEMBL16404411 | 0.88 | ROCK2 (0.34) | BDKRB1BACE1CHRM4ROCK2 | |
| SCHEMBL16404399 | 0.87 | ROCK2 (0.33) | BDKRB1BACE1ROCK2CNR1 | |
| SCHEMBL16404400 | 0.86 | BDKRB1 (0.34) | BDKRB1BACE1HTT | |
| SCHEMBL16404410 | 0.84 | EPHX2 (0.37) | BDKRB1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937073-B2 | Disubstituted tetrahydrofuranyl compounds and their use as B1-receptor antagonists | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-01-20 | — | — | US | disclosed |